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Pancreatic cancer
Late-stage symptoms of pancreatic cancer
Late symptoms of pancreatic cancer include abdominal pain, or sore and swollen back pain, as well as nausea, vomiting, decreased appetite, indigestion, and discomfort of upper abdominal fullness. These are some symptoms affecting the digestive tract. Additionally, there is jaundice caused by tumor compression of the bile duct, as well as skin itching, and even fever. Some patients show clinical manifestations such as ascites when there is metastasis to the liver, or abdominal or retroperitoneal lymph nodes.
What is used for pain relief in pancreatic cancer?
If a pancreatic cancer patient is experiencing pain, the choice of pain medication can be based on the specific severity of the pain. For mild pain, mild pain relievers such as ibuprofen sustained-release capsules can be chosen initially. For moderate pain, pain relievers like tramadol can be used. If the daily dosage of tramadol exceeds eight tablets, which is two tablets each time, taken every six hours, and if the pain relief is still inadequate after 24 hours, then it might be appropriate to switch to opioid painkillers such as hydromorphone sustained-release tablets, morphine sustained-release tablets, or morphine.
What are the symptoms of late-stage pancreatic cancer?
Some common symptoms of advanced pancreatic cancer include abdominal pain and upper abdominal pain, and it is even possible to feel an obvious lump in the abdomen. Jaundice is also a common symptom. Some patients may also experience nausea, vomiting, abdominal bloating, and abdominal pain, even ascites, which is a sensation of abdominal fullness. They are unable to eat, and eating can worsen the bloating. These clinical manifestations are accompanied by clearly noticeable abdominal pain. There are also symptoms associated with distant organ metastasis, such as when metastasis to the lungs can cause shortness of breath, coughing, and even hemoptysis. Some patients may experience extensive abdominal metastasis, which can even lead to intestinal obstruction and other clinical presentations.
How is pancreatic cancer diagnosed?
The most common symptoms of pancreatic cancer are pain in the upper abdomen and jaundice. During physical examination, a mass in the upper abdomen can be felt, which is a common symptom. When these symptoms appear, further abdominal ultrasound or CT scans should be performed, as these two are the most commonly used imaging methods for diagnosing pancreatic cancer. Additionally, pancreatic MRI or PET-CT can also help enhance the diagnostic accuracy for pancreatic cancer. MRCP and ERCP are also used to assess the bile ducts and to evaluate the feasibility of surgery. Blood tests for pancreatic cancer-related tumor markers, such as carcinoembryonic antigen (CEA) and CA19-9, are commonly performed, with CA19-9 being particularly sensitive and specific for the diagnosis of pancreatic cancer.
Which test for pancreatic cancer is the most accurate?
Abdominal ultrasound and abdominal CT scans are the most commonly used imaging methods for diagnosing pancreatic cancer. Additionally, it is important to consider the patient's symptoms and blood tests for tumor markers, mainly IP antigen, CEA, and CA19-9. Confirming pancreatic cancer requires a biopsy to find cancer cells, which is the gold standard for diagnosis. Other tests can serve as screening and adjunct diagnostic tools. Confirmation requires a biopsy for pathological diagnosis or direct radical surgery followed by a postoperative pathological confirmation.
What are the symptoms of pancreatic cancer?
The clinical manifestations of pancreatic cancer mainly depend on the location of the cancer, the stage of the disease, whether there is metastasis, and the involvement of adjacent organs. The clinical characteristics include a short disease course, rapid progression, and swift deterioration. The most common symptom is upper abdominal distension and discomfort, pain, though not all patients experience tenderness; if tenderness is present, it aligns with the area of pain felt. Pain is a primary symptom of pancreatic cancer, present whether the cancer is located in the head or the body/tail of the pancreas. Jaundice is a main symptom of cancer in the head of the pancreas, and patients often exhibit more severe gastrointestinal symptoms, most commonly loss of appetite, followed by nausea and vomiting. There might also be diarrhea or constipation, even melena. Diarrhea is often steatorrhea. In the early stages of pancreatic cancer, common symptoms include weight loss and fatigue.
How to screen for pancreatic cancer
Pancreatic cancer is a common malignant tumor of the digestive tract. Due to its high malignancy and rapid progression, it severely affects human health. So how should pancreatic cancer patients be screened? Generally, abdominal ultrasound examination is the primary screening method. Another method is the examination of tumor markers, mainly carcinoembryonic antigen (CEA) and CA19-9. CA19-9 is a tumor marker with relatively high specificity and sensitivity for the diagnosis of pancreatic cancer. Therefore, during physical examinations, we can draw blood to check these tumor markers. If there is a significant increase in CA19-9 or CEA, further examinations of the pancreas, such as ultrasound or CT of the pancreas, should be conducted to further investigate whether there is a tumor in the pancreas.
What to do about pancreatic cancer pain?
Pancreatic cancer pain is common in clinical practice, with some patients presenting with abdominal pain as their initial symptom. Pain management can be symptomatic, using analgesics for relief. For mild pain, tramadol can be chosen for pain relief. For severe pain, opioid analgesics such as morphine sustained-release tablets, oxycodone sustained-release tablets, or morphine tablets can be used for pain relief. These are merely symptomatic treatments. The fundamental approach involves surgical or oncological treatments like chemotherapy or radiotherapy to treat pancreatic cancer. Only when the tumor is controlled will the symptoms of pain be alleviated.
Reasons for the low resection rate of pancreatic cancer
The resection rate for pancreatic cancer is relatively low because the pancreas is located behind the peritoneum in a deep position. In the early stages of pancreatic cancer, there are often no specific clinical symptoms. Therefore, by the time pancreatic cancer is detected in patients, it is usually already in the advanced stages. The pancreas is surrounded by blood vessels and nerves. Therefore, if it is found in the late stage, the surgical difficulty is very high, making it difficult to remove surgically, which is why the surgical resection rate for pancreatic cancer is low.
What are the symptoms of pancreatic cancer?
The most common symptom of pancreatic cancer is abdominal pain, typically pain in the upper abdomen. Jaundice is also common, especially in cancers of the head of the pancreas, where it is the most frequent clinical manifestation. Upon physical examination, some patients may have a palpable mass in the upper abdomen. Other common symptoms include gastrointestinal issues, such as nausea, vomiting, a feeling of fullness after eating, and a decrease in appetite. These are some of the symptoms related to the digestive tract.