What should be done if pancreatic cancer has not metastasized?

Written by Liu Liang
Oncology
Updated on September 25, 2024
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If pancreatic cancer has not metastasized, then it might be in an early stage. In this situation, consultation with a hepatobiliary surgeon is necessary for the surgeon to assess whether curative surgery can be performed. If the surgeon determines that curative surgery is feasible, this should be the preferred treatment method. Post-operatively, based on whether there are symptoms of recurrence or metastasis, such as vascular tumor thrombi or lymph node metastases, decisions concerning the necessity for adjuvant radiotherapy or chemotherapy should be made based on these high-risk factors for recurrence and metastasis.

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Written by Zhou Chen
Oncology
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Pancreatic cancer is a type of cancer that arises from the pancreas.

The causes of pancreatic cancer are not yet entirely clear, but its occurrence is associated with smoking, drinking alcohol, high-fat and high-protein diets, excessive consumption of coffee, environmental pollution, and genetic factors. Recent surveys have found that the incidence of pancreatic cancer is significantly higher among diabetics than in the general population. There is also evidence suggesting a certain relationship between chronic pancreatitis and the development of pancreatic cancer, with a notably increased risk of pancreatic cancer among patients with chronic pancreatitis. Additionally, many other factors such as occupation, environment, and geography are somewhat related to the occurrence of this disease. Pancreatic cancer is not a cancer that comes from anger or emotional causes.

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Written by Zhou Chen
Oncology
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What are the symptoms of pancreatic cancer?

The clinical manifestations of pancreatic cancer mainly depend on the location of the cancer, the stage of the disease, whether there is metastasis, and the involvement of adjacent organs. The clinical characteristics include a short disease course, rapid progression, and swift deterioration. The most common symptom is upper abdominal distension and discomfort, pain, though not all patients experience tenderness; if tenderness is present, it aligns with the area of pain felt. Pain is a primary symptom of pancreatic cancer, present whether the cancer is located in the head or the body/tail of the pancreas. Jaundice is a main symptom of cancer in the head of the pancreas, and patients often exhibit more severe gastrointestinal symptoms, most commonly loss of appetite, followed by nausea and vomiting. There might also be diarrhea or constipation, even melena. Diarrhea is often steatorrhea. In the early stages of pancreatic cancer, common symptoms include weight loss and fatigue.

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Written by Liu Liang
Oncology
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What is used for pain relief in pancreatic cancer?

If a pancreatic cancer patient is experiencing pain, the choice of pain medication can be based on the specific severity of the pain. For mild pain, mild pain relievers such as ibuprofen sustained-release capsules can be chosen initially. For moderate pain, pain relievers like tramadol can be used. If the daily dosage of tramadol exceeds eight tablets, which is two tablets each time, taken every six hours, and if the pain relief is still inadequate after 24 hours, then it might be appropriate to switch to opioid painkillers such as hydromorphone sustained-release tablets, morphine sustained-release tablets, or morphine.

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Written by Zhou Chen
Oncology
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How is pancreatic cancer diagnosed?

Ultrasound, CT, MRI, ERCP (Endoscopic Retrograde Cholangiopancreatography), PTCD (Percutaneous Transhepatic Cholangio Drainage), angiography, laparoscopy, tumor markers measurement, cancer gene analysis, etc., are significantly helpful in confirming the diagnosis of pancreatic cancer and determining whether it is resectable surgically. Generally, ultrasound, CA199, and CEA can be used as screening tests. Once pancreatic cancer is suspected, a CT scan is necessary. If the patient has jaundice, especially severe, and a CT scan cannot confirm the diagnosis, ERCP and PTCD can be considered. If internal drainage is successful, surgery can be delayed for one to two weeks for patients with severe jaundice. The diagnostic value of MRI for pancreatic cancer is not superior to CT. If pancreatic cancer has been confirmed but it is uncertain whether it can be surgically removed, choosing angiography and laparoscopy is also clinically meaningful.

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Written by Liu Liang
Oncology
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The difference between pancreatic tumors and pancreatic cancer

Pancreatic tumors include benign and malignant tumors, with malignant pancreatic tumors commonly referred to as pancreatic cancer. Benign pancreatic tumors include insulinomas, pancreatic cysts, lipomas of the pancreas, or fibromas, which are relatively rare in clinical settings. Whether benign or malignant, including pancreatic cancer, symptoms can include upper abdominal pain, nausea, vomiting, and jaundice, among other clinical signs. However, distinguishing between benign and malignant tumors requires pathological examination.