In late-stage pancreatic cancer, bilateral lower extremity edema should be considered possibly due to hypoalbuminemia, which leads to edema in both legs. It is also possible that cancer emboli in late-stage pancreatic cancer block the venous system, causing impaired venous return and resulting in bilateral lower extremity edema. To determine the specific cause, it is necessary to complete ultrasonographic examinations of the blood vessels in the lower limbs, as well as liver function tests, complete blood count, and others. After clarifying the diagnosis, appropriate treatment measures should be taken based on the different causes. For example, if the edema is caused by hypoalbuminemia, active supplementation with albumin and diuretics, among other treatments, is required. (Note: The use of medications should be carried out under the guidance of a professional doctor.)