Patients with systemic lupus erythematosus (SLE) who develop a fever first need to discern whether the fever is due to immune-related fever caused by the activity of the disease or an infectious fever due to weakened immunity from long-term use of steroids and immunosuppressants. If the fever is caused by lupus activity, then it is necessary to increase the dosage of corticosteroids in treatment. If the fever is due to an infection, a full course of anti-infection treatment is needed. The anti-infection regimen may even need to include treatments with antibacterial, antifungal, and antiviral medications. (Please follow professional medical advice for medication use, and do not self-medicate.)