What causes systemic lupus erythematosus?

Written by Li Jing
Rheumatology
Updated on September 05, 2024
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Firstly, systemic lupus erythematosus belongs to autoimmune diseases and is a multisystemic autoimmune disorder. It is a chronic disease that cannot be cured. It can only be managed through medication to control the progression of the disease, prevent relapses, delay damage to other organs, and prevent complications. This is the overall principle of treatment. Its cause is currently unclear. It is only related to factors such as environmental pollution, viral infections, genetics, and hormones, according to expert research. However, there is no specific definitive cause identified.

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Written by Li Jing
Rheumatology
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What causes systemic lupus erythematosus?

Firstly, systemic lupus erythematosus belongs to autoimmune diseases and is a multisystemic autoimmune disorder. It is a chronic disease that cannot be cured. It can only be managed through medication to control the progression of the disease, prevent relapses, delay damage to other organs, and prevent complications. This is the overall principle of treatment. Its cause is currently unclear. It is only related to factors such as environmental pollution, viral infections, genetics, and hormones, according to expert research. However, there is no specific definitive cause identified.

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Written by Yang Ya Meng
Rheumatology
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What to do if systemic lupus erythematosus causes a fever?

Patients with systemic lupus erythematosus (SLE) who develop a fever first need to discern whether the fever is due to immune-related fever caused by the activity of the disease or an infectious fever due to weakened immunity from long-term use of steroids and immunosuppressants. If the fever is caused by lupus activity, then it is necessary to increase the dosage of corticosteroids in treatment. If the fever is due to an infection, a full course of anti-infection treatment is needed. The anti-infection regimen may even need to include treatments with antibacterial, antifungal, and antiviral medications. (Please follow professional medical advice for medication use, and do not self-medicate.)

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Written by Li Jing
Rheumatology
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Can systemic lupus erythematosus be cured?

Systemic lupus erythematosus is a multi-system autoimmune disease and a chronic condition with an unclear cause, making it incurable. Treatment primarily involves medication to control the progression of the disease, prevent relapse, and delay the onset of complications in other organs. The comprehensive goal of treatment is to manage these aspects. Additionally, exposure to direct sunlight should be avoided, and women should avoid oral contraceptives, as these can trigger active lupus. Furthermore, it's crucial to avoid consuming figs, bayberries, and other fruits that have been exposed to ultraviolet light over a long period, as they can also induce lupus activity.

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Written by Yang Ya Meng
Rheumatology
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Can systemic lupus erythematosus be cured?

Systemic lupus erythematosus is difficult to cure completely as it is a chronic disease that requires long-term, lifelong medication. The most basic drugs used to treat systemic lupus erythematosus are corticosteroids. Hydroxychloroquine is also a basic treatment for systemic lupus erythematosus, but it is necessary to rule out contraindications such as retinal problems before use. Some patients with systemic lupus erythematosus, if they also have kidney or lung involvement, may need to consider treatment with immunosuppressants after using corticosteroids. Commonly used immunosuppressants include mycophenolate mofetil and cyclophosphamide. (Medication should be taken under the guidance of a physician.)

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Written by Yang Ya Meng
Rheumatology
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Systemic lupus erythematosus symptoms

The symptoms of systemic lupus erythematosus mainly include fever, oral ulcers, facial erythema, including discoid and malar rash, photosensitivity, joint pain, polyserositis, including pleural effusion and pericardial effusion, as well as kidney involvement. The main manifestations are positive urinary protein, hematuria, and casts in the urine. Severe cases may have neurological involvement, presenting as epilepsy, mental disorders, or altered consciousness. Blood tests in these patients can further reveal positive ANA, anti-double-stranded DNA, and anti-Sm antibodies, as well as low complement levels. These are the related symptoms of systemic lupus erythematosus.