The causes of Parkinson's disease
Updated on March 09, 2025
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Parkinson's disease, also known as tremor paralysis, is a common neurodegenerative disorder. The cause of Parkinson's disease is not yet clear, but it may be related to several factors, such as aging, genetics, and environmental factors. Since Parkinson's disease is the result of multiple factors, including abnormal protein aggregation, oxidative stress, mitochondrial damage, inflammation, and excitotoxicity of glutamate, these elements lead to the loss of dopaminergic neurons in the substantia nigra of the midbrain and a reduction in dopamine neurotransmitters in the striatum. This ultimately results in the patient's bradykinesia, muscle rigidity, and resting tremor.
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