Is Parkinson's disease hereditary?

Written by Zhang Hui
Neurology
Updated on September 03, 2024
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Parkinson's disease is mainly divided into two types. One type is familial Parkinson's disease, which definitely has a clear genetic predisposition. This disease is caused by mutations in some genes that lead to disruptions in some internal environments and the accumulation of abnormal proteins, eventually causing the death of neurons. Since the disease is caused by genetic mutations, there is definitely a certain genetic predisposition, and reproductive counseling is necessary to prevent the birth of offspring with Parkinson's disease. Moreover, most cases of Parkinson's disease are sporadic, and these diseases may be related to acquired factors, such as long-term mental stress, excessive pressure, brain trauma, or cerebrovascular diseases in patients, which can all lead to Parkinson's disease. This type of disease is definitely not inherited, so there is no need to worry too much.

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Written by Zhang Hui
Neurology
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What department should Parkinson's disease go to?

Parkinson's disease is classified as a neurological disorder, so once considered for Parkinson's disease, registration is naturally in the department of neurology. Many neurologists are very familiar with Parkinson's disease and also have rich experience in diagnosis and treatment. Especially some neurology experts who specialize in Parkinson's disease have their own unique views on the pathogenesis, etiology, and clinical manifestations of the disease. Parkinson's disease is a chronic, degenerative neurological condition primarily divided into motor symptoms and non-motor symptoms, severely impacting the quality of life and work of patients. Symptoms include bradykinesia, resting tremor, muscle rigidity, etc. Treatment involves anticholinergic drugs and dopamine receptor agonists. (Note: This answer is for reference only. Medication should be administered under the guidance of a professional physician, and self-medication should be avoided.)

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Written by Zhang Hui
Neurology
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What medicine is used for Parkinson's disease?

Parkinson's disease is a relatively common neurological disorder, with a higher incidence in middle-aged and elderly people. Currently, there is no specific cure for the disease, but there are many medications that can significantly improve the symptoms of Parkinson's disease. The commonly used medications mainly include: The first major category is Levodopa preparations. This type of medication has good efficacy but can cause some adverse drug reactions and may provoke the occurrence of motor complications. It should be taken under the advice of a doctor. The second major category of drugs is dopamine receptor agonists. These drugs also have relatively good effects and can improve the motor symptoms of patients, though they may be a bit expensive. Third, anticholinergic drugs. They can significantly improve the patients' normal symptoms, but should not be taken by patients with cognitive impairments. Additionally, there are monoamine oxidase inhibitors and COMT inhibitors that can also be used.

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Written by Zhang Hui
Neurology
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Can Parkinson's disease be cured?

Parkinson's disease is a degenerative disease of the nervous system that currently cannot be cured in medicine. It is important to choose the right treatment plan to avoid being deceived. Parkinson's disease is mainly caused by the irreversible death of dopaminergic neurons in the substantia nigra, resulting in clinical manifestations such as bradykinesia, muscular rigidity, and tremors in limbs. Other non-motor symptoms include reduced sense of smell, constipation, anxiety, depression, and orthostatic hypotension. Treatment primarily focuses on symptomatic relief, and it is not expected to achieve complete remission. Commonly used medications include levodopa, anticholinergics, and activators of levodopa and dopamine receptors. Symptoms in patients usually progressively worsen, and curing the disease is very difficult.

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Neurology
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What is Parkinson's disease gait?

Patients with Parkinson's disease have a distinctive gait; typically, their torso leans forward, and their arms do not move much. When they walk, they exhibit a hurried gait with short, scurrying steps. That is, they take small steps that progressively get faster and faster, making stopping very difficult when they reach their destination. This is a typical scenario often referred to as a "scampering gait." Many experienced doctors can frame a preliminary diagnosis of Parkinson's disease just by observing the patient’s walk. Parkinson's disease also leads to unstable posture and gait, increasing the risk of falls and fractures. Therefore, it's important to take precautions at home by installing handrails to assist the patient in standing and walking, preventing accidental injuries.

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Written by Zhang Hui
Neurology
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What is needed to diagnose Parkinson's disease?

The definitive diagnosis of Parkinson's disease primarily relies on the patient's medical history, clinical manifestations, and a thorough physical examination by a neurologist. If the onset of the disease is very slow, presenting with symptoms such as bradykinesia and tremors, and the neurologist observes heightened muscle tone and slow movements during the examination, a high suspicion of this disease is warranted. Additionally, certain auxiliary tests are necessary, commonly including: First, testing the patient's sense of smell is crucial, as a reduced sense of smell is very important in diagnosing Parkinson's disease. Second, some brain MRI scans are needed mainly to exclude some secondary Parkinson's syndromes. Third, a brain PET-CT scan can be performed to examine the functionality of the striatum. Furthermore, an ultrasound of the substantia nigra in the midbrain can also be conducted, which holds significant value in assisting the diagnosis.