Cor pulmonale refers to the disease characterized by changes in the structure and function of the right ventricle due to increased pressure resistance in the pulmonary vessels, caused by abnormalities in the bronchopulmonary tissue, thoracic cage, pulmonary vessels, etc., ultimately leading to pulmonary arterial hypertension. Common symptoms of cor pulmonale observed clinically include coughing, production of phlegm, shortness of breath, chest tightness after activity, and difficulty breathing. Some individuals may experience respiratory failure and symptoms of heart failure. The severity of cor pulmonale depends firstly on the underlying causes of the disease. For instance, conditions like pulmonary embolism and pulmonary hypertension generally have a poorer and more serious prognosis. Secondly, extensive lung infections leading to a loss of cardiopulmonary compensation, resulting in respiratory failure and heart failure, typically indicate a more severe condition.