Cor pulmonale refers to a disease characterized by changes in heart structure and function due to increased pulmonary vascular resistance caused by pathological conditions of the bronchi, lungs, thoracic cage, or pulmonary vessels, leading to pulmonary arterial hypertension. This condition is collectively known as cor pulmonale. The clinical manifestations of cor pulmonale generally develop slowly. Clinically, in addition to pulmonary and pleural symptoms, there gradually appear signs of pulmonary cardiac failure and damage to other organs. Common symptoms include coughing, expectoration, palpitations, dyspnea, fatigue, decreased endurance to physical activity. In the decompensated stage, symptoms such as worsening dyspnea, headaches, insomnia, decreased appetite, and even some signs of right heart failure like palpitations, poor appetite, abdominal bloating, nausea, and swelling of the lower limbs may occur.