What are the clinical manifestations of thyroid cancer?

Written by Chen Xie
Endocrinology
Updated on September 14, 2024
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For patients with thyroid cancer, the most common clinical manifestation is thyroid nodules, and most patients do not have obvious clinical symptoms, only being incidentally discovered during physical examinations. In rare cases, patients may seek medical attention due to enlarged cervical lymph nodes. As the condition progresses, the neck mass gradually enlarges, becomes firmer, and its mobility decreases during swallowing. In some rapid developments, it may invade surrounding tissues, leading to late-stage symptoms such as hoarseness, difficulty breathing, and difficulty swallowing. When the cervical sympathetic nerve is compressed, it can cause pain in the ears, occipital region, and shoulders. In the case of medullary carcinoma, which can produce serotonin and calcitonin, patients may sometimes experience symptoms such as diarrhea, palpitations, facial flushing, or decreased blood calcium levels.

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Written by Gong Chun
Oncology
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Late-stage symptoms of thyroid cancer

Differentiated thyroid cancer, in its advanced stages, can exhibit noticeable symptoms due to large nodules or invasion of surrounding organs. For example, a massive nodule pressing on the trachea can cause breathing difficulties, including respiratory distress. Compression of the esophagus can lead to swallowing difficulties, and pressure on the recurrent laryngeal nerve may result in symptoms like hoarseness. Even very few benign thyroid nodules can cause edema and inflammation by compressing these nerves. Therefore, differentiation and distinctive treatment are essential, along with a pathological diagnosis. Medullary thyroid cancer also presents specific symptoms, including persistent diarrhea, endocrine syndromes, and other accompanying conditions such as pheochromocytoma, multiple mucosal neuromas, and symptoms and signs caused by parathyroid adenomas.

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Written by Yan Chun
Oncology
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Early symptoms and manifestations of thyroid cancer

Thyroid cancer is a common malignant tumor in the head and neck area. Early symptoms and signs primarily include a thyroid mass discovered incidentally during a physical examination. This type of mass grows quickly, leading to localized thyroid enlargement, and patients may experience discomfort when swallowing. Additionally, some thyroid cancer patients, due to abnormal hormone secretion, might experience unexplained skin flushing or sweating symptoms. Besides, early symptoms and manifestations of thyroid cancer are not typical, and many patients do not exhibit obvious symptoms. Instead, abnormalities in thyroid function are often incidentally found during physical examinations.

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Written by Gong Chun
Oncology
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Symptoms of thyroid cancer

The symptoms of thyroid cancer, the first point is the clinical manifestations of differentiated thyroid cancer. Most differentiated thyroid cancers are asymptomatic, with only occasional palpable nodules of varying sizes and textures, which can sometimes be detected in routine physical and imaging examinations. A few advanced thyroid cancers may produce noticeable symptoms due to large nodules or invasion of surrounding organs, such as compression of the trachea causing breathing difficulties, difficulty swallowing due to pressure on the esophagus, and hoarseness due to compression of the recurrent laryngeal nerve. The second point concerns the specific clinical manifestations of medullary thyroid carcinoma. The specific symptoms of medullary thyroid cancer include persistent watery diarrhea, not accompanied by severe malabsorption in the large intestine, often with facial flushing, some endocrine syndromes, and some associated conditions such as pheochromocytoma, multiple mucosal neuromas, and parathyroid adenomas.

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Written by Gan Jun
Endocrinology
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Does hypothyroidism lead to thyroid cancer?

Hypothyroidism and thyroid cancer are two different types of thyroid diseases; hypothyroidism does not cause thyroid cancer, and there is no necessary connection between the two. Hypothyroidism refers to a decrease in thyroid function levels, caused by abnormalities in the secretion and synthesis functions of the thyroid, closely related to disorders of the endocrine system. In contrast, thyroid cancer is a change in tissue nature due to malignant transformation in thyroid tissue cells, it is not related to the thyroid's endocrine functions, and currently, there is no research indicating that hypothyroidism increases the likelihood of developing thyroid cancer. Patients with thyroid diseases should undergo dynamic thyroid ultrasonography and monitoring of thyroid function to further clarify their condition.

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Written by Gong Chun
Oncology
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Early symptoms of thyroid cancer

Early symptoms of thyroid cancer: First, differentiated thyroid cancer often exhibits no symptoms in its early stages, only accidentally discovered nodules that vary in size and texture on the front of the neck. Some patients are only diagnosed during routine physical exams or through imaging studies, with clinical symptoms being relatively rare. However, more symptoms and signs may appear in the later stages. Second, medullary thyroid cancer presents some unique symptoms, such as persistent diarrhea, typically watery, and a syndrome involving the endocrine system. Patients may exhibit facial flushing, elevated blood pressure, and decreased blood calcium levels, accompanied by other conditions, such as parathyroid adenomas, multiple mucosal neuromas, and pheochromocytomas, which also manifest specific symptoms.