Late-stage symptoms of thyroid cancer

Written by Gong Chun
Oncology
Updated on September 19, 2024
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Differentiated thyroid cancer, in its advanced stages, can exhibit noticeable symptoms due to large nodules or invasion of surrounding organs. For example, a massive nodule pressing on the trachea can cause breathing difficulties, including respiratory distress. Compression of the esophagus can lead to swallowing difficulties, and pressure on the recurrent laryngeal nerve may result in symptoms like hoarseness. Even very few benign thyroid nodules can cause edema and inflammation by compressing these nerves. Therefore, differentiation and distinctive treatment are essential, along with a pathological diagnosis. Medullary thyroid cancer also presents specific symptoms, including persistent diarrhea, endocrine syndromes, and other accompanying conditions such as pheochromocytoma, multiple mucosal neuromas, and symptoms and signs caused by parathyroid adenomas.

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Written by Gan Jun
Endocrinology
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Does hypothyroidism lead to thyroid cancer?

Hypothyroidism and thyroid cancer are two different types of thyroid diseases; hypothyroidism does not cause thyroid cancer, and there is no necessary connection between the two. Hypothyroidism refers to a decrease in thyroid function levels, caused by abnormalities in the secretion and synthesis functions of the thyroid, closely related to disorders of the endocrine system. In contrast, thyroid cancer is a change in tissue nature due to malignant transformation in thyroid tissue cells, it is not related to the thyroid's endocrine functions, and currently, there is no research indicating that hypothyroidism increases the likelihood of developing thyroid cancer. Patients with thyroid diseases should undergo dynamic thyroid ultrasonography and monitoring of thyroid function to further clarify their condition.

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Written by Gong Chun
Oncology
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How is thyroid cancer diagnosed?

The first point is the diagnostic process for differentiated thyroid cancer. Initially, most patients may not have symptoms, while a minority might show symptoms due to invasion of surrounding organs. Ultrasound examination is the preferred method for diagnosing thyroid nodules. Ultrasound can clarify the number, nature, and location of thyroid nodules, as well as provide information on whether there are abnormally enlarged lymph nodes in the neck. It has a relatively high accuracy in identifying the nature of thyroid nodules. Currently, the most accurate test for determining the nature of thyroid nodules remains the fine needle aspiration cytology, which has a diagnostic sensitivity of 83-92% and specificity of 80-92%, but it is not 100% conclusive. The second point is about the diagnosis of medullary thyroid cancer. Besides the tests common for thyroid cancers, additional tests for medullary thyroid cancer can include fine needle aspiration, ultrasound, and some serological tests, such as calcitonin and carcinoembryonic antigen tests.

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Written by Yan Chun
Oncology
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What discomforts can thyroid cancer cause in the body?

Thyroid cancer is a common type of malignant tumor in the head and neck region. In its early stages, thyroid cancer has little effect on the body, and generally does not cause any discomfort. However, as the disease progresses and the tumor invades outward and metastasizes to distant areas, it can lead to various uncomfortable sensations. For example, if thyroid cancer invades surrounding tissues and organs, such as the recurrent laryngeal nerve, the patient may experience symptoms like a hoarse voice and choking while drinking. If thyroid cancer metastasizes to the cervical lymph nodes, the patient may also develop Horner's syndrome, which is characterized by a constricted pupil, drooping eyelid, and absence of sweating on the affected side of the face. If the patient develops superior vena cava syndrome, it can lead to difficulty breathing, chest pain, and swelling of the face and neck. If thyroid cancer metastasizes to the lungs or other distant areas, the patient may also experience chest pain, difficulty breathing, and coughing.

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Written by Gong Chun
Oncology
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Early symptoms of thyroid cancer

Differentiated thyroid cancer often has no symptoms in the early stages, with only incidental palpation of nodules of various sizes and textures on the front of the neck. Some patients may find abnormalities during routine physical examinations through imaging studies, and symptoms may appear only in the later stages. The second point concerns the characteristics of medullary thyroid cancer, which exhibits specific symptoms early on, such as persistent, watery diarrhea. Additionally, this cancer involves an endocrine syndrome, where tumor cells secrete calcitonin and adrenocorticotropic hormone, potentially leading to facial flushing, elevated blood pressure, and reduced blood calcium. This may be associated with other conditions such as pheochromocytoma, multiple mucosal neuromas, and parathyroid adenomas, which can also cause corresponding symptoms.

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Written by Gan Jun
Endocrinology
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Is thyroid swelling malignancy the same as thyroid cancer?

Thyroid malignancy refers to thyroid cancer, but even malignant thyroid cancer generally has a good prognosis. However, it is crucial to achieve early detection, diagnosis, and treatment. It is advised to promptly visit a thyroid specialty department for comprehensive examinations, including thyroid ultrasound, evaluation of thyroid function, and related thyroid antibodies. A fine needle aspiration biopsy should be conducted for a clear pathological diagnosis, followed by immediate active treatment, primarily surgical. Thyroid cancer includes papillary thyroid cancer, follicular thyroid cancer, medullary thyroid cancer, and undifferentiated cancer. The surgery mainly involves minimally invasive and traditional methods. Post-surgery, it is recommended to perform lymph node dissection, assess the extent of metastasis, and decide whether to proceed with Iodine-131 radiotherapy. Due to the loss of thyroid function, proactive thyroid hormone replacement therapy is advised, along with dynamic monitoring of thyroid health through ultrasound and related examinations.