Does hypothyroidism lead to thyroid cancer?

Written by Gan Jun
Endocrinology
Updated on December 17, 2024
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Hypothyroidism and thyroid cancer are two different types of thyroid diseases; hypothyroidism does not cause thyroid cancer, and there is no necessary connection between the two. Hypothyroidism refers to a decrease in thyroid function levels, caused by abnormalities in the secretion and synthesis functions of the thyroid, closely related to disorders of the endocrine system. In contrast, thyroid cancer is a change in tissue nature due to malignant transformation in thyroid tissue cells, it is not related to the thyroid's endocrine functions, and currently, there is no research indicating that hypothyroidism increases the likelihood of developing thyroid cancer. Patients with thyroid diseases should undergo dynamic thyroid ultrasonography and monitoring of thyroid function to further clarify their condition.

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Is a hypoechoic area definitely thyroid cancer?

A thyroid nodule underwent an ultrasound B-examination and showed hypoechoic features, but this does not necessarily indicate thyroid cancer. It is essential to conduct relevant tests to determine the cause. For such thyroid nodules, it is first important to check their specific size. If there is concern about the presence of a malignant tumor, it is advisable to perform a fine needle aspiration for pathological examination to confirm the diagnosis. If the thyroid nodule exceeds one centimeter and causes local pain or affects surrounding blood vessels, leading to symptoms of compression, it is recommended that patients should promptly undergo surgical removal for treatment.

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Written by Zhang Li
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The Differences between Thyroiditis, Hyperthyroidism, and Thyroid Cancer

Thyroiditis, hyperthyroidism, and thyroid cancer are clinically distinct conditions. Thyroiditis refers to inflammatory changes in the thyroid, either autoimmunity-related, suppurative or due to inflammation. Hyperthyroidism broadly refers to a functional change, which can result from various thyroid changes caused by diseases, including external damage and inflammation, leading to symptoms of hyperthyroidism. However, these manifestations should not be confused with each other, with the latter more closely related to autoimmune thyroiditis. Thyroid cancer, on the other hand, is a malignant alteration that also occurs in the thyroid gland but is not closely related to thyroiditis or hyperthyroidism. Generally, thyroid cancer is malignant, while thyroiditis and hyperthyroidism are benign, chronic conditions.

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Written by Gong Chun
Oncology
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Symptoms of thyroid cancer

The symptoms of thyroid cancer, the first point is the clinical manifestations of differentiated thyroid cancer. Most differentiated thyroid cancers are asymptomatic, with only occasional palpable nodules of varying sizes and textures, which can sometimes be detected in routine physical and imaging examinations. A few advanced thyroid cancers may produce noticeable symptoms due to large nodules or invasion of surrounding organs, such as compression of the trachea causing breathing difficulties, difficulty swallowing due to pressure on the esophagus, and hoarseness due to compression of the recurrent laryngeal nerve. The second point concerns the specific clinical manifestations of medullary thyroid carcinoma. The specific symptoms of medullary thyroid cancer include persistent watery diarrhea, not accompanied by severe malabsorption in the large intestine, often with facial flushing, some endocrine syndromes, and some associated conditions such as pheochromocytoma, multiple mucosal neuromas, and parathyroid adenomas.

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Oncology
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Early symptoms and manifestations of thyroid cancer

Thyroid cancer is a common malignant tumor in the head and neck area. Early symptoms and signs primarily include a thyroid mass discovered incidentally during a physical examination. This type of mass grows quickly, leading to localized thyroid enlargement, and patients may experience discomfort when swallowing. Additionally, some thyroid cancer patients, due to abnormal hormone secretion, might experience unexplained skin flushing or sweating symptoms. Besides, early symptoms and manifestations of thyroid cancer are not typical, and many patients do not exhibit obvious symptoms. Instead, abnormalities in thyroid function are often incidentally found during physical examinations.

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Is thyroid cancer without lymph node metastasis considered early stage?

Thyroid cancer, if it has not metastasized to lymph nodes, generally falls under early-stage. Once thyroid cancer is diagnosed, surgical removal is the primary treatment choice. Postoperative treatments vary depending on the different pathological types of thyroid cancer. For the most common type, papillary carcinoma, if the surgery is radically curative, further treatment may not be necessary, and merely supplementing thyroid hormones suffices. In cases such as follicular carcinoma, undifferentiated carcinoma, or medullary carcinoma, even after surgically radical removal, postoperative treatment often requires further radiotherapy or treatment with Iodine-131, depending on the surgical pathology results. (The use of medications should be carried out under the guidance of a professional doctor.)