Systemic lupus erythematosus is a multi-system, multi-damage autoimmune disease, primarily manifesting in the skin and mucous membranes. Some individuals may also experience low-grade fever and hair loss, even severe hair loss. If treatment has already commenced and hair loss continues during the treatment process, it is necessary to consider whether the medication dosage is insufficient and to consider adjusting the medication dosage. If medication has been discontinued and severe hair loss reoccurs, the first consideration should be whether there is a recurrence of active disease, necessitating a visit to the hospital for tests including a complete blood count, erythrocyte sedimentation rate, C-reactive protein, complement levels, and autoimmune antibodies to comprehensively assess whether the disease has relapsed. If the disease has relapsed, it is necessary to reintroduce steroids, adjust medication dosages, and combine the use of hydroxychloroquine to control the disease. (Specific medications should be used under the guidance of a physician.)