Systemic lupus erythematosus is an autoimmune disease that affects multiple systems and organs and is associated with a variety of autoimmune antibodies, primarily occurring in women of childbearing age. Its clinical manifestations are diverse, with the condition being mild and recurrently evolving. The most common symptoms involve changes to the skin, where various types of edematous erythema can occur, and in severe cases, there can be blisters, ulcers, erosion, skin atrophy, hyperpigmentation, and scar formation. Among these, the butterfly rash is most specific. Additionally, other symptoms may include joint swelling and pain; kidney involvement can lead to foamy urine, which is a common presentation; gastrointestinal involvement can cause diarrhea, and neurological involvement can lead to mental disorders and seizures. Therefore, once facial rashes, photosensitivity, or joint swelling and pain occur, it is crucial to be vigilant, undergo relevant examinations promptly, diagnose early, and treat early, as it is very important for the prognosis of the disease.