Ankylosing spondylitis is an autoimmune disease, primarily characterized by the involvement of the axial joints. This disease cannot be cured, but its progression can be controlled through medication to delay joint deformity, improve quality of life, and reduce disability rates, which are also the goals of treatment. Middle-aged or young males experiencing stiffness in the neck or pain in the lower back should seek comprehensive examinations, early diagnosis, and treatment as soon as possible.