What medicine is used for ankylosing spondylitis?

Written by Yang Ya Meng
Rheumatology
Updated on April 05, 2025
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The medication for ankylosing spondylitis mainly involves three aspects. The first is non-steroidal pain-relief medications, commonly including drugs like sustained-release diclofenac sodium tablets.

The second involves drugs that control the condition, commonly using medications like sulfasalazine and thalidomide.

The third, which is currently the most effective, involves treatment with biologics. Common biologics include tumor necrosis factor inhibitors. However, before using biologics, it is crucial to rigorously rule out complications such as hepatitis, tuberculosis, and tumors. Only after excluding these conditions should one consider using biologics.

Patients with ankylosing spondylitis should also pay attention to appropriate functional exercises in daily life to prevent the stiffening of spinal joints.

(Medications should be used under the guidance of a doctor, based on the specific situation.)

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Written by Yang Ya Meng
Rheumatology
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How to relieve ankylosing spondylitis

Methods to alleviate ankylosing spondylitis are as follows: First, in terms of lifestyle: during the remission phase of ankylosing spondylitis, it is necessary to persist in long-term functional exercises to keep the spine from adhering and becoming rigid. The second and most important aspect is the long-term use of medication. The medications used to treat ankylosing spondylitis mainly include the following categories: The first category is non-steroidal anti-inflammatory drugs, commonly used ones include diclofenac sodium sustained-release tablets, celecoxib capsules, etc.; the second category includes disease-controlling medications such as sulfasalazine, thalidomide, methotrexate, and even leflunomide. Currently, the most effective medications for treating ankylosing spondylitis are biologics. However, before using biologics, it is essential to strictly rule out diseases such as hepatitis, tuberculosis, and tumors. (Medications should be used under the guidance of a doctor based on specific conditions.)

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Written by Li Jing
Rheumatology
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Can people with ankylosing spondylitis work out?

Ankylosing spondylitis is an autoimmune disease that cannot be cured. It can only be managed with medication to control the condition, delay the onset of joint deformities, and reduce the rate of disability. Lifestyle changes are also a part of the treatment, including quitting smoking and drinking, and avoiding carbonated beverages as they can exacerbate bone loss. Additionally, regular exercise is important, with swimming being the best option. Swimming not only exercises the limbs and improves muscle coordination but also reduces joint wear and tear, making it the ideal form of exercise. For patients who cannot swim, other forms of exercise such as walking or running are also beneficial for fitness.

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Written by Li Jing
Rheumatology
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How to exercise with ankylosing spondylitis?

Once diagnosed with ankylosing spondylitis, after ruling out contraindications such as hepatitis B infection and tuberculosis, it is necessary to administer standard medications to improve rheumatic conditions. At the same time, it is necessary to develop good living habits, such as abstaining from alcohol, quitting smoking, and avoiding carbonated drinks and coffee, as these can exacerbate osteoporosis. Secondly, it is important to exercise regularly; one can walk slowly, run, or swim. Swimming is the best form of exercise for patients with ankylosing spondylitis as it can enhance the coordination of limb muscles while also delaying joint wear. Thirdly, it is important to maintain good posture and sleep on a hard bed.

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Written by Yang Ya Meng
Rheumatology
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What to do about ankylosing spondylitis pain?

The medications for treating pain in ankylosing spondylitis fall into three major categories: The first category includes non-steroidal anti-inflammatory drugs, such as sustained-release diclofenac sodium tablets. The second category consists of disease-controlling drugs, which are often immunosuppressants, such as methotrexate and sulfasalazine. Third, if patients still experience significant back pain despite using anti-inflammatory analgesics and disease-controlling drugs, biologic agents can be considered. The main biologics currently include tumor necrosis factor antagonists. (Note: The use of medications should be under the guidance of a doctor.)

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Written by Yang Ya Meng
Rheumatology
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What is the ESR level in ankylosing spondylitis?

Patients with ankylosing spondylitis, if not well controlled, can exhibit elevated erythrocyte sedimentation rates (ESR). An ESR higher than 20 mm per hour indicates elevation, suggesting poor disease control. At such times, it is necessary to utilize non-steroidal anti-inflammatory drugs (NSAIDs) such as sustained-release diclofenac sodium tablets. Additionally, medications that control the condition should also be used, like sulfasalazine tablets and thalidomide, among others. While biological agents, commonly tumor necrosis factor (TNF) antagonists, offer the best treatment effectiveness, they are also the most expensive. (The use of medications should be conducted under the guidance of a physician.)