Firstly, ankylosing spondylitis is an autoimmune disease primarily characterized by the destruction of axial joints, a chronic condition that can also manifest peripheral joint lesions. Currently, there are no definitive cures, meaning long-term medication is necessary to alleviate symptoms, control disease progression, delay joint deformity, reduce disability, and improve quality of life. This constitutes the overall goal of treatment. The preferred treatments are non-steroidal anti-inflammatory drugs (NSAIDs) and biologic agents. However, before using biologic agents, it is essential to complete routine blood tests, erythrocyte sedimentation rate, C-reactive protein, screenings for infectious diseases, and tuberculosis. After excluding infections, tuberculosis, and tumors, biologic agents can be administered. During the use of biologic agents, there is a risk of reduced immunity, making it easy to contract infections. Therefore, it is important to avoid getting cold, overwork, and to regularly recheck routine blood parameters, liver, and kidney functions.