How is nasopharyngeal carcinoma diagnosed?

Written by Li Rui
Otolaryngology
Updated on September 09, 2024
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The examination of nasopharyngeal carcinoma is mainly divided into two major categories. The first category is imaging examinations, and the second category is pathological biopsy tests. Imaging examinations primarily involve performing a CT or MRI of the nasopharyngeal area to determine the scope of the cancerous changes in the nasopharynx, which is quite helpful for clinical staging and typing. It also plays a role in designing targeted therapy for subsequent radiation treatment. Pathological testing is an important means for diagnosing nasopharyngeal carcinoma. Generally, it requires a nasopharyngoscopy. If cancerous changes are suspected during the nasopharyngoscopy, a pathological biopsy can be taken simultaneously. After the biopsy, the specific differentiation degree and type of cancer can be determined. Then, in conjunction with the imaging examinations, a plan for radiotherapy and chemotherapy can be formulated.

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Causes of Nasopharyngeal Carcinoma

Nasopharyngeal carcinoma is a highly prevalent malignant tumor in China, especially common in the Guangdong and Guangxi regions, as well as other coastal areas including Hunan, Fujian, and Jiangxi. These regions are among the highest incidence areas for nasopharyngeal carcinoma worldwide. The incidence rate in males is three times that of females, with the age group of 40 to 50 years being particularly at risk. The occurrence of nasopharyngeal carcinoma is associated with genetic, viral, and environmental factors, exhibiting racial and familial patterns. In areas like Guangzhou and the Pearl River Delta, it is possible for five out of nine people in the same family to have nasopharyngeal carcinoma. Infection with the Epstein-Barr virus is also one of the causes of nasopharyngeal carcinoma, in addition to environmental factors. Areas with low trace elements in rice and water, as well as low fluoride levels, are prone to higher incidences of this cancer. Patients with nasopharyngeal carcinoma typically have higher fluoride levels in their hair, and nitrites are also one of the major contributing factors to the condition.

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How to check for nasopharyngeal carcinoma?

Nasopharyngeal carcinoma is a malignant tumor in the nasal area, clinically mainly squamous cell carcinoma. The incidence of nasopharyngeal carcinoma is relatively high in southern regions of our country. Clinically, the primary treatment is radiotherapy. For diagnosis, the first general step involves using an electronic nasopharyngoscope to examine the nasopharyngeal area for suspicious conditions. Further imaging studies can also be conducted, such as CT scans and MRI scans of the nasopharyngeal area. Through these examinations, if a neoplasm in the nasal area is essentially identified and suspected to be nasopharyngeal carcinoma, an endoscopic examination is conducted where forceps are used to clip tissue for a pathological biopsy. The pathological biopsy determines whether it is definitively nasopharyngeal carcinoma and identifies the type of cancer cells, thus guiding clinical treatment.

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Written by Li Rui
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Do people with nasopharyngeal carcinoma lose weight?

Some patients with nasopharyngeal carcinoma may experience weight loss, but individual differences exist. This is somewhat related to the condition itself as well as to the individual's resistance and their baseline physical fitness. If the condition is detected early and the clinical symptoms are not particularly obvious, most patients will not show significant weight loss, and many people may not have noticeable symptoms. If the condition is severe, and diet and nutrition are not properly managed in a timely manner, patients may experience weight loss, especially in advanced stages of the illness. This can result in a cachectic-like state, which poses greater challenges for treatment. It is necessary to seek medical attention promptly, assess the physical condition, and consider the need for radiotherapy and chemotherapy.

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Is nasopharyngeal carcinoma contagious?

Nasopharyngeal carcinoma currently has no definite transmissibility, and the exact cause of nasopharyngeal cancer is not particularly clear. Clinical studies have shown that there is a certain relationship between nasopharyngeal carcinoma and EB virus infection, but it may also be related to other factors, such as familial heredity or living environment. Exposure to radioactive or chemical substances may also have a certain impact. Currently, there is no evidence to suggest that there is genetic or absolute contagion. Overall, in terms of treatment, radiotherapy is mainly used, and some patients need to be combined with chemotherapy. Generally, the five-year survival rate is relatively high among early-stage patients. If the disease staging is later and the differentiation is poor, the treatment difficulty and treatment effect are relatively worse.

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What department should I go to for nasopharyngeal carcinoma?

Nasopharyngeal carcinoma is a relatively common type of malignant tumor in the head and neck area. In terms of treatment, if a patient has been diagnosed with nasopharyngeal carcinoma, it is recommended to consult an oncology department or a radiation therapy department. This disease requires consideration of a comprehensive treatment plan involving radiotherapy and chemotherapy, typically spanning several months, and regular follow-ups are needed to monitor recovery. If the diagnosis has not yet been confirmed, it is necessary to first consult an otolaryngology (ENT) department. After visiting the ENT department, a nasopharyngoscopy can be performed, followed by a biopsy under the guidance of the nasopharyngoscopy. Only after the pathology from the biopsy can the specific diagnosis of nasopharyngeal carcinoma be confirmed, allowing for the clinical pathological staging and typing necessary for subsequent treatment.