How to check for nasopharyngeal carcinoma?

Written by Deng Bang Yu
Otolaryngology
Updated on August 31, 2024
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Nasopharyngeal carcinoma is a malignant tumor in the nasal area, clinically mainly squamous cell carcinoma. The incidence of nasopharyngeal carcinoma is relatively high in southern regions of our country. Clinically, the primary treatment is radiotherapy. For diagnosis, the first general step involves using an electronic nasopharyngoscope to examine the nasopharyngeal area for suspicious conditions. Further imaging studies can also be conducted, such as CT scans and MRI scans of the nasopharyngeal area. Through these examinations, if a neoplasm in the nasal area is essentially identified and suspected to be nasopharyngeal carcinoma, an endoscopic examination is conducted where forceps are used to clip tissue for a pathological biopsy. The pathological biopsy determines whether it is definitively nasopharyngeal carcinoma and identifies the type of cancer cells, thus guiding clinical treatment.

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Written by Deng Bang Yu
Otolaryngology
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What are the symptoms of nasopharyngeal carcinoma?

Nasopharyngeal carcinoma is a malignant, space-occupying lesion in our nasopharynx. Clinically, the initial symptoms are those of the nasopharynx, manifesting as discomfort in the nasopharyngeal area, or blood in nasal discharge when sniffling. As the nasopharyngeal carcinoma tissue enlarges, it can block the posterior nasal apertures, leading to nasal congestion, rapid breathing, and difficulty in breathing. The tumor tissue pressing on our Eustachian tube can cause secretory middle ear infections. The metastasis of nasopharyngeal carcinoma cells to our cervical lymph nodes causes swelling of these lymph nodes. Destruction of the cranial structure by nasopharyngeal carcinoma tissues presents symptoms such as headaches. There are also other symptoms, mainly due to the spread of nasopharyngeal carcinoma throughout the body or its metastasis to other parts causing corresponding symptoms.

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Written by Deng Bang Yu
Otolaryngology
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Distinction between Nasopharyngitis and Nasopharyngeal Carcinoma

Nasopharyngitis and nasopharyngeal carcinoma have fundamental differences. Nasopharyngitis is an inflammatory disease, while nasopharyngeal carcinoma is a malignant tumor disease. Clinically, nasopharyngitis mainly presents with increased secretions in the nasopharyngeal area, sometimes with a slight amount of bloody secretions, but this is extremely rare. On the other hand, nasopharyngeal carcinoma primarily shows symptoms such as the proliferation of malignant tumor tissues in the nasopharynx, enlargement of the lymph nodes in the neck, headaches, and ear stuffiness. In terms of treatment, nasopharyngitis is primarily treated with medications, such as traditional Chinese medicines, nasal sprays, and nasal corticosteroids; whereas nasopharyngeal carcinoma is primarily treated with radiotherapy combined with chemotherapy, which is currently the common sandwich therapy. Overall, there are fundamental differences between the two.

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Written by Li Rui
Otolaryngology
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Can stage IV nasopharyngeal cancer be cured?

Nasopharyngeal carcinoma is a relatively common type of malignant tumor in the head and neck region. If it is stage IV nasopharyngeal carcinoma, achieving clinical cure is very difficult; only a small portion of patients have the chance to achieve clinical cure, as stage IV nasopharyngeal carcinoma is considered advanced. The current common treatments are a combination of radiotherapy and chemotherapy. During the treatment process, regular reviews are necessary to observe the effects of the treatment. Some patients respond well to the treatment, and the tumor can be completely eliminated after treatment; however, for some patients, the treatment can only control the rapid growth of the tumor, not completely eradicate it. Even if the tumor completely subsides, there might still be a chance of local recurrence or distant metastasis after the treatment ends.

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Written by Yao Jun
Otolaryngology - Head and Neck Surgery
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Causes of Nasopharyngeal Carcinoma

Nasopharyngeal carcinoma is a highly prevalent malignant tumor in China, especially common in the Guangdong and Guangxi regions, as well as other coastal areas including Hunan, Fujian, and Jiangxi. These regions are among the highest incidence areas for nasopharyngeal carcinoma worldwide. The incidence rate in males is three times that of females, with the age group of 40 to 50 years being particularly at risk. The occurrence of nasopharyngeal carcinoma is associated with genetic, viral, and environmental factors, exhibiting racial and familial patterns. In areas like Guangzhou and the Pearl River Delta, it is possible for five out of nine people in the same family to have nasopharyngeal carcinoma. Infection with the Epstein-Barr virus is also one of the causes of nasopharyngeal carcinoma, in addition to environmental factors. Areas with low trace elements in rice and water, as well as low fluoride levels, are prone to higher incidences of this cancer. Patients with nasopharyngeal carcinoma typically have higher fluoride levels in their hair, and nitrites are also one of the major contributing factors to the condition.

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Written by Deng Bang Yu
Otolaryngology
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Can nasopharyngeal carcinoma be treated?

Nasopharyngeal carcinoma is a common clinical disease, especially in the southern regions of China. It primarily affects the nasal area as a malignant tumor. The clinical treatment outcomes for nasopharyngeal carcinoma are relatively good, and it is also referred to as "fortunate cancer," which implies that it has a relatively high cure rate. The main clinical treatment involves radiation therapy combined with chemotherapy, often described as the "sandwich" treatment method. Any tumor can be cured if detected early, and the early detection rate of nasopharyngeal carcinoma is relatively high. Therefore, its cure rate is also relatively high compared to other major organ tumors such as liver and lung cancers, which exhibit relatively lower cure rates and outcomes.