Nasopharyngeal carcinoma brain metastasis symptoms

Written by Li Rui
Otolaryngology
Updated on January 16, 2025
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Nasopharyngeal carcinoma is a relatively common type of head and neck malignant tumor. If brain metastasis from nasopharyngeal carcinoma occurs, it may cause related clinical symptoms. Common symptoms include headaches, dizziness, decreased vision, and visual field defects. Additionally, some patients may experience fever, but there is significant variability in clinical symptoms among individuals. In such cases, it is necessary to visit departments such as otolaryngology, neurology, and oncology. A head MRI can be conducted to assess the extent of the condition. Generally, options like radiation therapy and chemotherapy are available. With timely treatment, some patients can still achieve a relatively long survival time.

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Nasopharyngeal carcinoma clinical manifestations

Nasopharyngeal carcinoma is the most common malignant tumor in the nasopharyngeal area, and clinically, it is primarily squamous cell carcinoma. The incidence of nasopharyngeal carcinoma is particularly high in the southern regions of China, especially in Guangdong. Initially, nasopharyngeal carcinoma manifests locally as a tumorous mass in the nasopharyngeal area, often with ulceration on the surface. This can lead to the presence of blood in nasal mucus, known as bloody nasal discharge. As the disease progresses, there can be swelling of the cervical lymph nodes, primarily involving the upper deep cervical lymph nodes, with about 60% of patients experiencing this type of lymph node enlargement. As the tumor enlarges, it may block the nasal passage, leading to persistent nasal congestion. The tumor's pressure on the Eustachian tube can cause symptoms of secretory otitis media. Furthermore, damage to the skull base by the tumor can lead to severe headaches. As a malignant tumor, the cancer can cause systemic symptoms such as malnutrition and cachexia. In advanced stages, metastatic symptoms may appear, such as bone and liver metastases, affecting these vital organs.

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Can stage IV nasopharyngeal cancer be cured?

Nasopharyngeal carcinoma is a relatively common type of malignant tumor in the head and neck region. If it is stage IV nasopharyngeal carcinoma, achieving clinical cure is very difficult; only a small portion of patients have the chance to achieve clinical cure, as stage IV nasopharyngeal carcinoma is considered advanced. The current common treatments are a combination of radiotherapy and chemotherapy. During the treatment process, regular reviews are necessary to observe the effects of the treatment. Some patients respond well to the treatment, and the tumor can be completely eliminated after treatment; however, for some patients, the treatment can only control the rapid growth of the tumor, not completely eradicate it. Even if the tumor completely subsides, there might still be a chance of local recurrence or distant metastasis after the treatment ends.

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Early symptoms of nasopharyngeal carcinoma

The symptoms of nasal cancer can be numerous. In the early stages, symptoms might not be apparent because the area affected is relatively small, which can make the symptoms unclear. Possible symptoms include bloody nasal discharge and poor nasal airflow. Some patients might experience a foreign body sensation in the nasopharyngeal area. The most important thing, however, is to use diagnostic aids to make an assessment. This can include a nasopharyngoscopy, an enhanced CT of the nasopharynx, or an enhanced MRI to preliminarily determine the presence of a tumor. If a tumor is suspected, it is possible to consider performing a biopsy and lab tests under endoscopy. Only after completing the biopsy and lab tests can it be confirmed whether it is nasopharyngeal cancer, and then further treatment plans can be considered.

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What should I do if nasopharyngeal carcinoma causes vomiting?

Patients with nasopharyngeal carcinoma who exhibit vomiting should first determine the cause of the vomiting. For instance, if vomiting is due to the gastrointestinal reactions caused by radiotherapy and chemotherapy, medications such as serotonin receptor antagonists, corticosteroids, and NK-1 receptor blockers should be used to alleviate the side effects of the treatment. Additionally, nasopharyngeal carcinoma patients might experience projectile vomiting due to brain metastasis, which results in increased intracranial pressure. It is essential first to confirm the presence of brain metastasis through CT and MRI scans of the head. If brain metastasis is confirmed, localized treatment such as radiotherapy should be administered. Medications like mannitol and glycerol fructose should be used concurrently to reduce intracranial pressure and relieve the projectile vomiting. (Please use medications under the guidance of a doctor.)

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Can nasopharyngeal carcinoma be cured?

Nasopharyngeal carcinoma cannot be completely cured, as it is a malignant tumor, and malignant tumors cannot be completely cured worldwide. Nasopharyngeal carcinoma refers to the malignant tumors that occur at the top or lateral walls of the nasopharynx. The common clinical cause is viral infection, most commonly associated with the Epstein-Barr virus, causing dryness, pain, and itching in the nasopharynx, along with backflow, blood in sputum, and swollen lymph nodes in the neck. Patients need to undergo a detailed examination with an electronic nasopharyngoscope and a CT scan of the nasopharynx for diagnosis. If an abnormal neoplasm is found, local pathological treatment is required. Once confirmed as malignant, local radiation therapy, chemotherapy, and surgical treatment are also needed. After surgery, patients need to undergo regular follow-up examinations, and further treatment may be required if abnormal proliferation is found.