Causes of Nasopharyngeal Carcinoma

Written by Yao Jun
Otolaryngology - Head and Neck Surgery
Updated on September 17, 2024
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Nasopharyngeal carcinoma is a highly prevalent malignant tumor in China, especially common in the Guangdong and Guangxi regions, as well as other coastal areas including Hunan, Fujian, and Jiangxi. These regions are among the highest incidence areas for nasopharyngeal carcinoma worldwide. The incidence rate in males is three times that of females, with the age group of 40 to 50 years being particularly at risk. The occurrence of nasopharyngeal carcinoma is associated with genetic, viral, and environmental factors, exhibiting racial and familial patterns. In areas like Guangzhou and the Pearl River Delta, it is possible for five out of nine people in the same family to have nasopharyngeal carcinoma. Infection with the Epstein-Barr virus is also one of the causes of nasopharyngeal carcinoma, in addition to environmental factors. Areas with low trace elements in rice and water, as well as low fluoride levels, are prone to higher incidences of this cancer. Patients with nasopharyngeal carcinoma typically have higher fluoride levels in their hair, and nitrites are also one of the major contributing factors to the condition.

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Written by Yao Jun
Otolaryngology - Head and Neck Surgery
1min 11sec home-news-image

Causes of Nasopharyngeal Carcinoma

Nasopharyngeal carcinoma is a highly prevalent malignant tumor in China, especially common in the Guangdong and Guangxi regions, as well as other coastal areas including Hunan, Fujian, and Jiangxi. These regions are among the highest incidence areas for nasopharyngeal carcinoma worldwide. The incidence rate in males is three times that of females, with the age group of 40 to 50 years being particularly at risk. The occurrence of nasopharyngeal carcinoma is associated with genetic, viral, and environmental factors, exhibiting racial and familial patterns. In areas like Guangzhou and the Pearl River Delta, it is possible for five out of nine people in the same family to have nasopharyngeal carcinoma. Infection with the Epstein-Barr virus is also one of the causes of nasopharyngeal carcinoma, in addition to environmental factors. Areas with low trace elements in rice and water, as well as low fluoride levels, are prone to higher incidences of this cancer. Patients with nasopharyngeal carcinoma typically have higher fluoride levels in their hair, and nitrites are also one of the major contributing factors to the condition.

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Written by Deng Bang Yu
Otolaryngology
48sec home-news-image

Can nasopharyngeal carcinoma be treated?

Nasopharyngeal carcinoma is a common clinical disease, especially in the southern regions of China. It primarily affects the nasal area as a malignant tumor. The clinical treatment outcomes for nasopharyngeal carcinoma are relatively good, and it is also referred to as "fortunate cancer," which implies that it has a relatively high cure rate. The main clinical treatment involves radiation therapy combined with chemotherapy, often described as the "sandwich" treatment method. Any tumor can be cured if detected early, and the early detection rate of nasopharyngeal carcinoma is relatively high. Therefore, its cure rate is also relatively high compared to other major organ tumors such as liver and lung cancers, which exhibit relatively lower cure rates and outcomes.

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Written by Deng Bang Yu
Otolaryngology
59sec home-news-image

What are the symptoms of late-stage nasopharyngeal carcinoma?

Nasopharyngeal cancer is a common malignancy in otolaryngology, primarily located in the nasopharyngeal area. In advanced stages, nasopharyngeal cancer manifests symptoms in two main aspects. One involves symptoms directly caused by the cancer or its metastasis, typically presenting as increased nasal masses, enlarged cervical lymph nodes, severe headaches, decreased hearing, and bleeding in the nasal area due to tumor cells or tissue eroding the internal carotid artery. Additionally, there is a foul smell from the nasopharyngeal area. The second aspect relates to systemic symptoms due to the growth of nasopharyngeal cancer, leading to poor overall nutritional status and cachexia, characterized by extreme emaciation. There is also the potential for distant metastasis of the tumor cells, presenting symptoms in the corresponding areas.

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Written by Zhang Jun
Otolaryngology
1min 5sec home-news-image

Can nasopharyngeal carcinoma be cured?

Nasopharyngeal carcinoma cannot be completely cured, as it is a malignant tumor, and malignant tumors cannot be completely cured worldwide. Nasopharyngeal carcinoma refers to the malignant tumors that occur at the top or lateral walls of the nasopharynx. The common clinical cause is viral infection, most commonly associated with the Epstein-Barr virus, causing dryness, pain, and itching in the nasopharynx, along with backflow, blood in sputum, and swollen lymph nodes in the neck. Patients need to undergo a detailed examination with an electronic nasopharyngoscope and a CT scan of the nasopharynx for diagnosis. If an abnormal neoplasm is found, local pathological treatment is required. Once confirmed as malignant, local radiation therapy, chemotherapy, and surgical treatment are also needed. After surgery, patients need to undergo regular follow-up examinations, and further treatment may be required if abnormal proliferation is found.

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Written by Li Rui
Otolaryngology
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What is nasopharyngeal carcinoma?

Nasopharyngeal carcinoma is a relatively common malignant tumor in the nasopharyngeal area, and the main pathological type is predominantly squamous carcinoma, most of which are poorly differentiated squamous carcinomas, constituting the most common malignant tumor in the nasopharyngeal area. Currently, the primary treatment option is radiotherapy, which is the most important; some patients may need to consider concurrent or adjuvant chemotherapy. If drug and radiotherapy treatments are ineffective, or if there is cervical lymph node metastasis, and for some patients where chemoradiotherapy fails with residual lesions, surgery may be considered. However, currently, the surgical treatment approach is generally not very mature and is somewhat controversial, thus it requires treatment at major hospitals.