What are the symptoms of iron deficiency anemia?

Written by He Li Fang
Hematology
Updated on September 08, 2024
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Iron deficiency anemia is a type of anemia that exhibits common symptoms found in all anemia patients. It is characterized by a range of clinical symptoms caused by oxygen deficiency in tissue organs due to a lack of blood in the body. Common symptoms include dizziness, headaches, fatigue, shortness of breath and palpitations after activity, easy fatigability, difficulty concentrating, and decreased memory. Some patients may also experience blurred vision, ringing in the ears, and in severe cases, fainting, transient darkening of vision, and even arrhythmias. Because iron deficiency anemia is also accompanied by iron deficiency, it presents a range of clinical symptoms specific to iron deficiency, including pica, angular cheilitis, glossitis, unusual tongue conditions, decreased appetite, and even constipation among other symptoms.

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Written by He Li Fang
Hematology
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Characteristics of iron deficiency anemia blood picture

The clinical manifestations of iron deficiency anemia are due to the specific characteristics of anemia caused by iron deficiency and the underlying disease causing the iron deficiency. Its hematological characteristics present as typical microcytic hypochromic anemia. What does this concept mean? It refers to the values in a complete blood count where MCV is less than 80 femtoliters, MCH is less than 27 picograms, and MCHC is less than 30%. MCV refers to the average red blood cell volume, MCH refers to the mean corpuscular hemoglobin concentration, and MCHC refers to the mean corpuscular hemoglobin concentration of red blood cells. The extent of changes in red blood cell indices correlates with the duration and severity of anemia. The blood smear typically shows pale-stained red blood cells with an enlarged central pallor and varying sizes. Platelet count often tends to be high when there is concurrent bleeding and generally tends to be low in infants and children. White blood cell count is usually normal or slightly reduced, with normal differential. These are the hematological characteristics of iron deficiency anemia.

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Hematology
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Iron deficiency anemia clinical manifestations

Iron deficiency anemia presents in a variety of ways, including symptoms of anemia and iron deficiency. The main manifestation is tissue and organ hypoxia caused by iron deficiency, and severe iron deficiency anemia can lead to mucosal tissue changes and ectoderm nutritional disorders. Among the symptoms, we can find that in the early stages, the symptoms are relatively concealed and hard to detect. Patients with a slow progression can often adapt well in the early stages and are able to engage in daily work. Common symptoms of anemia include dizziness, headache, fatigue, and tiredness, along with palpitations and shortness of breath after activity, and even symptoms such as blurred vision and tinnitus. For patients with iron deficiency, specific symptoms include angular cheilitis, atrophy of the tongue papillae, glossitis, and severe iron deficiency patients may experience koilonychia, decreased appetite, nausea, and even constipation. Some patients, particularly children during their growth periods, may exhibit delayed growth and behavioral abnormalities, specifically being irritable and easily angered, having difficulty concentrating in class, and declining academic performance. A few patients may also develop pica, which is a special manifestation of iron deficiency anemia. In terms of physical signs, patients may exhibit pallor of the skin and mucous membranes, dry hair, and keratinization of the lips. Nails may be flat, lackluster, and prone to breakage, and a small number of patients may experience mild splenomegaly. These are the clinical manifestations of iron deficiency anemia.

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Written by He Li Fang
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What is the fastest way to treat iron deficiency anemia?

Iron deficiency anemia is a type of anemia caused by a lack of storage iron in the body, affecting the synthesis of hemoglobin. It is characterized by a lack of available iron in tissues and organs such as bone marrow, liver, and spleen, with decreased serum iron concentration, transferrin saturation, and serum ferritin levels. Typically, iron deficiency anemia presents as microcytic hypochromic anemia. Iron, as one of the essential trace elements in the human body, is contained in all functioning cells and is broadly involved in metabolic processes within the body. Therefore, the treatment principle for iron deficiency anemia involves replenishing sufficient iron until normal iron stores are restored and addressing the underlying causes that led to the iron deficiency to effectively and quickly replenish iron. Oral iron supplements are the preferred treatment option for iron deficiency anemia, such as ferrous sulfate, ferrous succinate, and iron dextran which are effective oral iron agents.

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The key to curing iron deficiency anemia

Iron deficiency anemia, a common and frequently occurring disease in the department of hematology, is not difficult to diagnose and treat. The key to treatment lies in addressing the cause of the iron deficiency, and it is essential to eliminate the underlying causes as much as possible. Using iron supplements alone can only restore blood counts; neglecting the primary disease will not lead to a complete cure of the anemia and can easily lead to recurrence. Treatment consists of two phases: first, the supplementation with iron supplements. After taking iron supplements for three to four days, an increase in reticulocytes will occur, reaching a peak around seven days, and hemoglobin will significantly rise after two weeks of medication, returning to normal levels after one to two months. However, after hemoglobin levels normalize, some patients may stop taking the medication. It is important to note that continuing to take iron supplements for three months is necessary to replenish the body's iron stores completely.

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Iron deficiency anemia has the following symptoms:

The clinical manifestations and symptoms of iron deficiency anemia mainly include symptoms of both anemia and iron deficiency. Symptoms in patients with anemia often include dizziness, headache, shortness of breath and palpitations after activity, difficulty concentrating, easy fatigue, blurred vision, tinnitus, and other symptoms. There are also specific signs of iron deficiency such as cheilitis, glossitis, and atrophy of the tongue papillae. In terms of physical signs, we can find that some patients may have spoon nails. Regarding appetite, some patients may experience reduced appetite, nausea, and even constipation, all of which are general symptoms of iron deficiency anemia. Severe cases may even exhibit transient syncope, visual obscurity, and pica as clinical manifestations.