Iron deficiency anemia clinical manifestations

Written by He Li Fang
Hematology
Updated on September 28, 2024
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Iron deficiency anemia presents in a variety of ways, including symptoms of anemia and iron deficiency. The main manifestation is tissue and organ hypoxia caused by iron deficiency, and severe iron deficiency anemia can lead to mucosal tissue changes and ectoderm nutritional disorders. Among the symptoms, we can find that in the early stages, the symptoms are relatively concealed and hard to detect. Patients with a slow progression can often adapt well in the early stages and are able to engage in daily work. Common symptoms of anemia include dizziness, headache, fatigue, and tiredness, along with palpitations and shortness of breath after activity, and even symptoms such as blurred vision and tinnitus. For patients with iron deficiency, specific symptoms include angular cheilitis, atrophy of the tongue papillae, glossitis, and severe iron deficiency patients may experience koilonychia, decreased appetite, nausea, and even constipation. Some patients, particularly children during their growth periods, may exhibit delayed growth and behavioral abnormalities, specifically being irritable and easily angered, having difficulty concentrating in class, and declining academic performance. A few patients may also develop pica, which is a special manifestation of iron deficiency anemia. In terms of physical signs, patients may exhibit pallor of the skin and mucous membranes, dry hair, and keratinization of the lips. Nails may be flat, lackluster, and prone to breakage, and a small number of patients may experience mild splenomegaly. These are the clinical manifestations of iron deficiency anemia.

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Written by He Li Fang
Hematology
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What to eat for dietary supplementation in iron deficiency anemia

The dietary plan for patients with iron-deficiency anemia first involves increasing the intake of iron-rich foods, such as animal liver, blood, soybeans, black fungus, sesame paste, brown sugar, lean meat, egg yolks, pork and lamb kidneys, and dried fruits. Second, it is recommended to appropriately supplement with vitamin C, as taking iron supplements and vitamin C together can increase iron absorption, thereby achieving better iron supplementation effects. Thirdly, patients are advised to change their dietary habits to increase the intake and bioavailability of nutrients like vitamin A, vitamin B2, folic acid, and vitamin B12, which are involved in the production of red blood cells. Supplementing these nutrients can also enhance the utilization of iron from food, thereby assisting in the treatment.

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Written by He Li Fang
Hematology
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How long does iron deficiency anemia need to be treated?

Patients with iron deficiency anemia typically need several months of iron supplementation treatment. The specific reason is that after taking iron supplements, patients' subjective symptoms can recover quickly. The count of reticulocytes generally begins to rise within three to four days after starting the medication, reaching a peak around seven days. Hemoglobin levels notably increase within two weeks of treatment, and generally return to normal around two months. After correcting anemia, it is necessary to continue treatment for at least another three months because the body's iron stores need further supplementation. It is necessary to restore serum ferritin levels to fifty micrograms per liter to replenish these stores fully. This is required to achieve a true cure of iron deficiency anemia, as without this, patients are prone to relapse. Therefore, regular and long-term effective use of iron supplements is an essential basis for ensuring the treatment effectiveness of iron deficiency anemia.

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Written by He Li Fang
Hematology
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What is the fastest way to treat iron deficiency anemia?

Iron deficiency anemia is a type of anemia caused by a lack of storage iron in the body, affecting the synthesis of hemoglobin. It is characterized by a lack of available iron in tissues and organs such as bone marrow, liver, and spleen, with decreased serum iron concentration, transferrin saturation, and serum ferritin levels. Typically, iron deficiency anemia presents as microcytic hypochromic anemia. Iron, as one of the essential trace elements in the human body, is contained in all functioning cells and is broadly involved in metabolic processes within the body. Therefore, the treatment principle for iron deficiency anemia involves replenishing sufficient iron until normal iron stores are restored and addressing the underlying causes that led to the iron deficiency to effectively and quickly replenish iron. Oral iron supplements are the preferred treatment option for iron deficiency anemia, such as ferrous sulfate, ferrous succinate, and iron dextran which are effective oral iron agents.

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Written by He Li Fang
Hematology
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Symptoms of iron deficiency anemia

The clinical manifestations of iron deficiency anemia consist of symptoms due to the anemia itself, specific manifestations of iron deficiency, and the underlying diseases causing the iron deficiency. The onset of anemia is often insidious, with some patients progressing very slowly. Initially, patients can adapt well to daily life and continue with their work, making it difficult to detect. It is usually not until the anemia becomes moderate to severe and symptoms become apparent that it is discovered. Common symptoms of anemia include dizziness, headaches, weakness, easy fatigue, palpitations, and shortness of breath after activity. Some patients might also experience a decline in memory and suffer from tinnitus and blurred vision. Some affected children may exhibit delayed growth and development or even abnormal behaviors, which can manifest as irritability, restlessness, inattention in class, and declining academic performance. A few patients may develop pica, a specific manifestation of iron deficiency anemia. Additionally, some patients might suffer from angular cheilitis, glossitis, and even atrophy of the tongue papillae. Severe cases can experience transient blindness and fainting, hence it is crucial to seek medical attention for iron deficiency anemia at the earliest.

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Written by He Li Fang
Hematology
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Treatment of Iron Deficiency Anemia

The treatment principles for iron deficiency anemia mainly involve two aspects. One is to identify the cause of the iron deficiency anemia. Once the cause is confirmed, fundamental treatment of the cause should be conducted to restore the body's normal iron stores. The second aspect is iron supplementation, which is recommended to be administered orally. The daily supplemental iron dose is approximately 150 to 200 milligrams, typically using ferrous preparations such as ferrous succinate, ferrous fumarate, ferrous gluconate, and iron dextran. It is suggested that iron supplements be taken with meals or after meals to reduce gastrointestinal irritation caused by the medication. Additionally, it is advised to avoid consuming tea, coffee, and other substances that could interfere with iron absorption during the treatment period.