Hand, foot and mouth disease is an infectious disease caused by enteroviruses. There are more than 20 types of enteroviruses that cause hand, foot and mouth disease, among which Coxsackievirus A16 and Enterovirus 71 are the most common. Its main clinical symptoms include mouth pain, decreased appetite, mild fever, and the appearance of small vesicles or small ulcers on the hands, feet, mouth, and other areas. Most infected children can recover in about a week. The rash of hand, foot and mouth disease typically appears on the hands, feet, buttocks, arms, and legs as maculopapular rash, which can later turn into vesicles. These vesicles are surrounded by an inflammatory red halo and contain relatively little fluid. The rash is not itchy. Thus, the rash of hand, foot and mouth disease is unlike other allergic rashes; it does not cause itching or discomfort.