Hand, foot, and mouth disease is caused by an intestinal virus infection and is characterized by acute fever and vesicles or papules on the hands, feet, mouth, buttocks, and other areas. There are more than 20 types of enteroviruses that cause this disease, with the most common being Enterovirus 71 and Coxsackievirus A16. In typical cases, the fever may last about two to three days, but there are also cases with mild symptoms where no fever appears, or only a low fever occurs, lasting one to two days. In severe cases, the fever may last longer, from three to five days or even more. Therefore, it can only be said that in most cases, the fever in typical cases may last about two to three days.