Hand, foot, and mouth disease is caused by an intestinal virus, mainly manifested in children as blisters on the hands, feet, mouth, and buttocks. Some cases may involve fever, while others may have no fever or only mild, low-grade fever. Oral and pharyngeal blisters are quite common, causing oral pain and discomfort. Many children who contract hand, foot, and mouth disease experience a decrease in appetite, which is related to oral and pharyngeal blisters causing pain that affects swallowing and eating.