Hand, foot, and mouth disease is a common pediatric disease caused by an intestinal viral infection, characterized by fever and rash, with severities ranging from mild to severe. If caused by a typical enterovirus infection, hand, foot, and mouth disease generally recovers quickly with antiviral treatment and proper care of the mouth and skin. However, if caused by an EV71 virus infection, it poses certain risks. This is because the EV71 virus can affect the central nervous system, leading to symptoms such as increased intracranial pressure and respiratory and circulatory dysfunction. These complications can result in respiratory failure and cardiac failure, which are severe manifestations. Therefore, hand, foot, and mouth disease caused by the EV71 virus carries certain risks. Thus, it is important to administer a vaccine made from the EV71 virus to children to prevent severe hand, foot, and mouth disease.