Is hand, foot, and mouth disease dangerous?

Written by Yao Li Qin

Pediatrics

Updated on November 22, 2024

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Hand, foot, and mouth disease is a common pediatric disease caused by an intestinal viral infection, characterized by fever and rash, with severities ranging from mild to severe. If caused by a typical enterovirus infection, hand, foot, and mouth disease generally recovers quickly with antiviral treatment and proper care of the mouth and skin. However, if caused by an EV71 virus infection, it poses certain risks. This is because the EV71 virus can affect the central nervous system, leading to symptoms such as increased intracranial pressure and respiratory and circulatory dysfunction. These complications can result in respiratory failure and cardiac failure, which are severe manifestations. Therefore, hand, foot, and mouth disease caused by the EV71 virus carries certain risks. Thus, it is important to administer a vaccine made from the EV71 virus to children to prevent severe hand, foot, and mouth disease.

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Written by Yan Xin Liang

Pediatrics

56sec

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Symptoms of hand, foot, and mouth disease

Hand, foot, and mouth disease is a disease caused by enterovirus that results in sores on the hands, feet, mouth, and buttocks, accompanied by symptoms such as fever. It is generally caused by Enterovirus 71 or Coxsackievirus A16. Most cases of hand, foot, and mouth disease are typical and may involve fever, low fever, or no fever at all. However, common symptoms include sores in the mouth and on the pharynx, as well as on the hands, feet, and buttocks. The general course of the disease lasts five to seven days, but severe cases may last longer. Severe cases may present with symptoms such as listlessness, irritability, vomiting, and trembling limbs. More serious conditions can include microcirculatory disorders, difficulty breathing, shortness of breath, neurogenic edema, and bleeding, among others.

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Written by Yao Li Qin

Pediatrics

1min 7sec

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Hand, foot and mouth disease characteristics

Hand, foot, and mouth disease is an infectious disease caused by enterovirus, primarily characterized by scattered maculopapular or vesicular rashes on the hands, feet, mouth, and buttocks. These rashes are quite distinctive; initially, there is a fever, followed by rashes on hands and feet. These are commonly found between the fingers, starting as maculopapular rashes and gradually turning into vesicular rashes. The rashes, measuring three to seven millimeters, have a firm base with slightly thickened skin over the blisters and are surrounded by erythema. They occur mainly on the extremities but can sometimes spread to the arms, legs, buttocks, or perineal area. The distribution of the rash is centrifugal, ranging from a few to dozens in number. Generally, the rashes absorb on their own within two to three days without scaling, scarring, or pigmentation, and oral blisters or ulcers usually heal within a week.

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Written by Yan Xin Liang

Pediatrics

1min

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Late-stage symptoms of hand, foot, and mouth disease

Hand, foot, and mouth disease is an acute infectious disease caused by enterovirus infection. Generally, there are more than twenty types of enteroviruses that cause hand, foot, and mouth disease, but the most common are Coxsackie virus A16 and enterovirus 71. The initial symptoms of hand, foot, and mouth disease are blisters in the hands, feet, and mouth; some cases include fever, while others do not. In later stages, the disease may exhibit recurring fevers, and the blisters on the mouth, hands, feet, and buttocks may burst and crust over. After crusting, the blisters gradually heal, but in some cases, the disease can progress to severe cases. For instance, complications such as encephalitis, brainstem encephalitis, myocarditis can occur, and some cases may develop neurogenic pulmonary edema, pulmonary hemorrhage, and circulatory failure, among others. However, such severe cases are generally rare.

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Written by Yao Li Qin

Pediatrics

1min 17sec

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Characteristics of hand, foot, and mouth disease rash

Hand, foot, and mouth disease is a rash disease caused by an intestinal virus infection, characterized by scattered maculopapular and vesicular rashes on the hands, feet, buttocks, and other areas. Typically, small vesicles appear on the oral mucosa, or they may already have ruptured into shallow ulcers, primarily located on the tongue, buccal mucosa, palate, and inner lips. Subsequently, rashes appear on the hands and feet, most commonly as maculopapules, which then develop into vesiculopapules about three to seven millimeters in size. The vesicles have a relatively thick covering and are surrounded by reddened skin, predominantly located at the extremities. Sometimes, they may extend to the arms, legs, buttocks, or perineal area. The distribution of the rash is centrifugal, with the number of lesions varying from a few to dozens. Generally, the lesions absorb on their own within two to three days without desquamation, scarring, or pigmentation. The vesicles and ulcers in the mouth mostly heal on their own within a week.

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Written by Yao Li Qin

Pediatrics

1min

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Hand, foot, and mouth disease transmission routes

Hand, foot, and mouth disease is caused by an intestinal virus infection, characterized by a rash of scattered maculopapular and vesicular lesions on the hands, feet, mouth, and buttocks. Generally, the prognosis is good. The disease is quite contagious, primarily spreading through the gastrointestinal tract, respiratory tract, and close contact. Therefore, during peak seasons of hand, foot, and mouth disease, children should stay at home and avoid crowded places and playing with children who have the disease. The highest incidence of this disease is among children under three years old, so it is essential to pay attention to the prevention and health care of infants. If a child in kindergarten is found to have the disease, they should rest at home and not return to the kindergarten immediately.