Hand, foot, and mouth disease is an infectious disease caused by enterovirus infection. There are more than 20 common types of enteroviruses, with Coxsackievirus A16 and Enterovirus 71 being the most common. The main clinical symptoms include fever, mouth pain, loss of appetite, and small blisters or ulcers on the hands, feet, and mouth. Most affected children can heal on their own in about a week, so ordinary cases can be isolated for about a week until all the rashes have crusted over and disappeared. However, for severe cases, the isolation period should be extended appropriately, possibly lasting 10-14 days, or even longer.