Symptoms of ovarian cancer

Written by Liu Liang
Oncology
Updated on September 07, 2024
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Ovarian cancer patients, especially those in the early stages, typically have inconspicuous symptoms, possibly without any noticeable discomfort. The disease is often discovered during gynecological examinations through the detection of abdominal masses. In advanced-stage patients, as the abdominal mass progressively enlarges, symptoms may include abdominal pain, lower abdominal bloating, and pelvic pressure symptoms due to compression of nearby organs. There may be partial intestinal obstruction, presenting as nausea, vomiting, abdominal pain, and inability to pass stool or gas. Another symptom is ascites, characterized by progressive enlargement and bloating of the abdomen. Ascites is a common clinical manifestation in ovarian cancer patients, and a significant portion of patients are diagnosed with ovarian cancer after presenting with ascites as the initial symptom.

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Written by Liu Liang
Oncology
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ovarian cancer specific drug

Ovarian cancer does not have any specific cure-all treatment. Most ovarian cancers are epithelial ovarian cancers, and there is also ovarian cancer resulting from malignant germ cells, which is a rarer pathology type. For epithelial ovarian cancer, treatment methods include surgery, radiation therapy, chemotherapy, and some targeted therapies, mainly using Bevacizumab, which is a monoclonal antibody that inhibits angiogenesis, and is usually used in combination with chemotherapy drugs. For patients with advanced ovarian cancer, those who are resistant to chemotherapy, or those in poor general health unable to endure chemotherapy, palliative treatments like hormone treatment using progestogens are an option, along with immune therapy being available nowadays. Surgery is primarily for early-stage ovarian cancer patients, where curative surgical resection is possible, or for debulking surgery in patients with advanced ovarian cancer. Chemotherapy is frequently used as it is relatively effective for epithelial ovarian cancer, a type of cancer that is somewhat sensitive to such treatments. The drugs used mainly include taxane combined with platinum-based chemotherapy. For intravenous administration or intraperitoneal delivery—for the latter, mainly for ovarian cancers complicated by extensive ascites—, positioning an abdominal drainage tube and then infusing platinum-based chemotherapy drugs into the abdominal cavity are utilized.

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Oncology
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Is chemotherapy effective after the recurrence of ovarian cancer?

After the recurrence of ovarian cancer, most patients can still benefit from chemotherapy again, as ovarian cancer itself is relatively sensitive to chemotherapy compared to other types of malignant tumors. If the recurrence occurs more than six months after the initial treatment, the same chemotherapy drugs used initially can still be chosen. However, if the recurrence happens within six months, the chemotherapy plan should include different drugs that were not used previously.

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Written by Liu Liang
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Will ovarian cancer recur after complete resection?

After complete removal of ovarian cancer, there is still a possibility of recurrence, especially in patients with high-risk factors. The recurrence rate can be quite high, for example, if there was rupture of the capsule, low differentiation of the pathology, presence of tumor tissue on the surface of the ovary, severe adhesion of the tumor to the surrounding areas, cancer cells found in the abdominal lavage fluid, or presence of vascular tumor thrombus and nerve invasion. Even after total removal, recurrence can still occur.

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Written by Wu Xia
Oncology
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Can ovarian cancer be inherited?

Ovarian cancer, like most tumors, has genetic factors involved in its etiology, but it is not a genetic disease. Only five to ten percent of ovarian cancer patients have a genetic background. More than ninety percent of ovarian cancer cases are sporadic, meaning that if a mother has ovarian cancer, it does not directly inherit to her daughter. However, individuals with a family history of ovarian cancer have a significantly higher risk of developing the disease compared to the general population, especially those who carry mutations in the BRCA1 and BRCA2 genes. These gene mutations can be inherited from parents, so individuals carrying these mutations have a significantly higher risk of developing ovarian cancer than the healthy population.

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Oncology
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Is ovarian cancer hereditary?

The onset of ovarian cancer may be somewhat related to family history or genetic factors. Therefore, patients with a family history of ovarian cancer may have a higher risk of developing the disease compared to the general population. However, this doesn't mean that a patient with ovarian cancer will definitely pass the condition to their offspring; it merely indicates a certain level of heredity. Furthermore, for those with a family history of breast cancer, colon cancer, and endometrial cancer, it is crucial for their descendants to undergo enhanced screenings for ovarian cancer and these diseases, as their risk of developing these conditions may be higher than that of the average person.