Can ovarian cancer be inherited?

Written by Wu Xia
Oncology
Updated on March 25, 2025
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Ovarian cancer, like most tumors, has genetic factors involved in its etiology, but it is not a genetic disease. Only five to ten percent of ovarian cancer patients have a genetic background. More than ninety percent of ovarian cancer cases are sporadic, meaning that if a mother has ovarian cancer, it does not directly inherit to her daughter. However, individuals with a family history of ovarian cancer have a significantly higher risk of developing the disease compared to the general population, especially those who carry mutations in the BRCA1 and BRCA2 genes. These gene mutations can be inherited from parents, so individuals carrying these mutations have a significantly higher risk of developing ovarian cancer than the healthy population.

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How is ovarian cancer diagnosed?

Ovarian cancer is discovered through transvaginal ultrasound of the adnexa uteri revealing ovarian tumors, or through imaging studies such as abdominal CT scans or MRIs showing ovarian tumors, combined with tumor markers, particularly the ovarian epithelial cancer tumor marker CA125, which will be significantly elevated. Generally, with these findings, ovarian cancer can typically be clinically diagnosed. Confirmation, however, requires pathological diagnosis, which involves obtaining a biopsy of the tumor. This can be done through a puncture biopsy or through pathological examination after surgical excision to confirm ovarian cancer. Additionally, some patients with ovarian cancer present with substantial ascites at the time of discovery. If cancer cells are found in the abdominal fluid, combined with a significant increase in CA125 and imaging studies showing ovarian tumors, ovarian cancer can also be diagnosed.

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Symptoms of ovarian cancer brain metastasis

Patients with ovarian cancer experiencing brain metastases are relatively uncommon in clinical settings. The primary symptom of brain metastasis is intracranial hypertension, which includes severe headaches, dizziness, nausea, and vomiting, including projectile vomiting during meals — all symptoms of increased intracranial pressure. Additionally, if there is significant brain swelling, the patient may experience weakness in the limbs on the opposite side of the body, similar to symptoms of paralysis seen in stroke patients. Furthermore, if the brain metastasis leads to the formation of a brain herniation, the patient may experience symptoms such as coma.

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What causes ovarian cancer?

The causes of ovarian cancer, and its mechanism of onset, are not yet very clear. Some risk factors that have been relatively well established in relation to the occurrence of ovarian cancer include early menarche, which means starting menstruation at an earlier age, late menopause, and not having a history of pregnancy; these conditions are some of the risk factors for ovarian cancer. Additionally, the occurrence of ovarian cancer is also somewhat related to familial or genetic factors.

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Ovarian Cancer Dietary Precautions

The occurrence of ovarian cancer is not greatly related to dietary habits, so there are no special dietary restrictions or forbidden foods for patients with ovarian cancer. In Western medicine, unlike Traditional Chinese Medicine, which mentions certain "stimulating foods," there are no such prohibitions. Therefore, the diet for patients with ovarian cancer is the same as for anyone else, only requiring a balanced, comprehensive nutrition, and a combination of meat and vegetables. There are no special dietary considerations needed.

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Does ovarian cancer hyperthermic intraperitoneal chemotherapy work?

Patients with ovarian cancer are prone to peritoneal metastasis, so many patients develop ascites during the discovery of the disease or its progression. A large amount of ascites is a common concurrent symptom in patients with ovarian cancer. For patients with significant ascites like this, hyperthermic intraperitoneal chemotherapy (HIPEC) can be performed, which involves infusing chemotherapy drugs into the abdominal cavity and then combining it with thermotherapy. This treatment generally has a decent effect, especially in controlling the spread of cancer cells in the peritoneum and managing ascites.