Prostate cancer IV is stage 4.

Written by Cui Fang Bo
Oncology
Updated on November 09, 2024
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Prostate cancer stage IV refers to stage four prostate cancer, which is a common type of male reproductive organ tumor, particularly prevalent among elderly men. Stage four prostate cancer means that the tumor is not confined to the prostate and has already shown corresponding distant metastasis. The most common sites of metastasis for prostate cancer are the bones, followed by the lungs, liver, and others. When metastasis of prostate cancer occurs, it is considered to be at a late stage, and the primary treatments include endocrine therapy, chemotherapy, etc., with a poor prognosis.

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What are the symptoms of bone metastasis from prostate cancer?

Bone metastasis is the most common site of metastasis for prostate cancer, with the lumbar vertebrae being the most common site. Eighty percent of bone metastases in prostate cancer are osteoblastic changes. The main symptoms caused by bone metastasis are bone pain, pathological fractures, anemia, and if the spinal cord is compressed, it can cause paralysis of the lower limbs, weakness, incontinence, and other symptoms.

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What causes prostate cancer?

The current causes of prostate cancer are not completely understood, but a large amount of research indicates that genetic and environmental factors play a significant role. Dietary factors, such as the intake of a large amount of unsaturated fatty acids, vasectomy, smoking, obesity, and alcohol consumption, also increase the risk of developing prostate cancer. Overall, the occurrence and development of prostate cancer are related to various factors, including both internal causes in the patient and the influence of external factors.

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Written by Zhou Zi Hua
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Commonly used drugs for endocrine treatment of prostate cancer

The purpose of endocrine therapy for prostate cancer is to reduce the concentration of androgens in the body, inhibit the synthesis of androgens originating from the adrenal glands, inhibit the conversion of testosterone to dihydrotestosterone, or block the binding of androgens to their receptors, thereby inhibiting or controlling the growth of prostate cancer cells. The medications include a luteinizing hormone-releasing hormone analogue, with representative drugs being leuprorelin, goserelin, and triptorelin. There is also an androgen-blocking drug, including steroidal drugs with representative drugs like cyproterone acetate, and non-steroidal drugs with representative drugs like bicalutamide and flutamide. Additionally, there are estrogens, with the most common being diethylstilbestrol.

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Where can prostate cancer metastasize to?

When prostate cancer invades surrounding tissues and structures, it can cause a variety of clinical symptoms, including urinary irritation, urinary obstruction, urinary incontinence, sciatica, erectile dysfunction, etc., and can compress causing unilateral or bilateral hydronephrosis. In severe cases, when the tumor invades the rectum, it can cause difficulty in defecation or colon obstruction. When the cancer metastasizes to the bones, it can cause bone pain and pathological fractures, and may also spread to the lungs.

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Is prostate cancer sexually transmitted?

Prostate cancer is non-contagious; therefore, it cannot be transmitted through sharing utensils, eating together, or through respiratory pathways. Secondly, prostate cancer is not transmitted through sexual activity; it is non-contagious. In clinical settings, many family members of patients inquire whether malignant tumors are contagious and if they could be infected while caring for the patient. It is important to clarify that malignant tumors are not contagious, and prostate cancer cannot be transmitted through sexual activity.