Commonly used drugs for endocrine treatment of prostate cancer

Written by Zhou Zi Hua
Oncology
Updated on September 06, 2024
00:00
00:00

The purpose of endocrine therapy for prostate cancer is to reduce the concentration of androgens in the body, inhibit the synthesis of androgens originating from the adrenal glands, inhibit the conversion of testosterone to dihydrotestosterone, or block the binding of androgens to their receptors, thereby inhibiting or controlling the growth of prostate cancer cells. The medications include a luteinizing hormone-releasing hormone analogue, with representative drugs being leuprorelin, goserelin, and triptorelin. There is also an androgen-blocking drug, including steroidal drugs with representative drugs like cyproterone acetate, and non-steroidal drugs with representative drugs like bicalutamide and flutamide. Additionally, there are estrogens, with the most common being diethylstilbestrol.

Other Voices

doctor image
home-news-image
Written by Zhou Zi Hua
Oncology
37sec home-news-image

What causes prostate cancer?

The current causes of prostate cancer are not completely understood, but a large amount of research indicates that genetic and environmental factors play a significant role. Dietary factors, such as the intake of a large amount of unsaturated fatty acids, vasectomy, smoking, obesity, and alcohol consumption, also increase the risk of developing prostate cancer. Overall, the occurrence and development of prostate cancer are related to various factors, including both internal causes in the patient and the influence of external factors.

doctor image
home-news-image
Written by Zhou Zi Hua
Oncology
51sec home-news-image

Endocrine therapy after radical prostatectomy for prostate cancer

Endocrine therapy after radical prostatectomy for prostate cancer is equivalent to adjuvant endocrine therapy for prostate cancer. Its purpose is to treat residual lesions, positive residual lymph nodes, and microscopic metastatic foci, thereby improving long-term survival rates. Currently, the indications for adjuvant endocrine therapy are based on postoperative pathology-positive results, positive lymph nodes post-surgery, and postoperative pathology confirmation of stage T3 or T4, but with high-risk factors. According to major guidelines, the duration of adjuvant endocrine therapy should be at least eighteen months.

doctor image
home-news-image
Written by Liu Liang
Oncology
43sec home-news-image

Is prostate cancer prone to metastasis?

Prostate cancer most commonly metastasizes to bones, with multiple bone metastases frequently observed clinically. In fact, the majority of prostate cancer patients already have multiple bone metastases by the time they are diagnosed. Therefore, bone is the most common distant organ to which prostate cancer spreads. Other distant organ metastases, such as to the lungs and liver, are less common, unless in very advanced stages of the disease. Additionally, prostate cancer commonly invades locally, spreading to nearby pelvic structures and tissues, such as the bladder and rectum, which is a common form of local invasion and spread.

doctor image
home-news-image
Written by Yan Chun
Oncology
56sec home-news-image

Is vomiting in prostate cancer due to metastasis to the liver?

Patients with prostate cancer may experience vomiting due to the metastasis of the disease to the liver, causing damage to liver function. However, vomiting could also be caused by other reasons, such as the metastasis of prostate cancer to the peritoneum of the abdominal cavity. Clinically, this can lead to cancerous intestinal obstruction, with symptoms commonly including vomiting, abdominal pain, bloating, reduced bowel movements and gas, or cessation of bowel movements and gas. When prostate cancer metastasizes to the brain, the increased intracranial pressure can also cause symptoms such as vomiting, headache, swelling of the optic disc, hemiplegia, and aphasia. Additionally, some prostate cancer patients may experience vomiting due to toxic side effects from treatments such as chemotherapy and targeted therapy.

doctor image
home-news-image
Written by Zhou Zi Hua
Oncology
40sec home-news-image

Prostate Cancer Treatment Options

How is prostate cancer treated? The choice of treatment plan should be based on a comprehensive consideration of the patient's clinical stage, age, overall health, and expected lifespan. For example, in the early stages of prostate cancer, one can choose postoperative radical radiotherapy after prostatectomy. For locally advanced prostate cancer, radiotherapy, intensified radiotherapy combined with endocrine therapy can be chosen. For metastatic prostate cancer, endocrine therapy is mainly used, and chemotherapy can be adopted for those who are ineffective or fail endocrine therapy.