In general, if a patient is diagnosed with pericardial effusion, troponin levels might also increase under stress conditions. This is because troponin is primarily used as a marker to assess myocardial infarction. An increase in troponin levels suggests the possibility of a myocardial infarction. However, under stress conditions, especially with pericardial effusion, troponin levels can rise. During this period, it is also advisable to perform an electrocardiogram or a cardiac echocardiography on the patient for a more definitive diagnosis. A mere increase in troponin levels does not conclusively indicate a problem; it is necessary to consider the patient’s current symptoms and results from other diagnostic tests.