Causes of Dementia

Written by Zhang Hui
Neurology
Updated on September 27, 2024
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At present, the specific causes and mechanisms of Alzheimer's disease are not very clear, but they are mainly divided into two categories. The first category is hereditary, where some Alzheimer's disease cases have a clear family history and involve some genetic mutations. These genetic mutations lead to the deposition of abnormal proteins within neurons, causing irreversible neuronal death, which is the main reason for familial Alzheimer’s disease. The second category is sporadic Alzheimer’s disease, for which no clear pathogenesis has been identified. Research suggests that factors such as oxidative stress, trauma, cerebrovascular disease, cerebral ischemia, and other factors, including metabolic conditions leading to dementia, are related to the occurrence of sporadic Alzheimer's disease. Therefore, the causes of Alzheimer’s disease include two main categories: the first is caused by genetic mutations, and the second is caused by various adverse factors leading to neuronal death.

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Written by Zhang Hui
Neurology
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Causes of Dementia

At present, the specific causes and mechanisms of Alzheimer's disease are not very clear, but they are mainly divided into two categories. The first category is hereditary, where some Alzheimer's disease cases have a clear family history and involve some genetic mutations. These genetic mutations lead to the deposition of abnormal proteins within neurons, causing irreversible neuronal death, which is the main reason for familial Alzheimer’s disease. The second category is sporadic Alzheimer’s disease, for which no clear pathogenesis has been identified. Research suggests that factors such as oxidative stress, trauma, cerebrovascular disease, cerebral ischemia, and other factors, including metabolic conditions leading to dementia, are related to the occurrence of sporadic Alzheimer's disease. Therefore, the causes of Alzheimer’s disease include two main categories: the first is caused by genetic mutations, and the second is caused by various adverse factors leading to neuronal death.

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Written by Zhang Hui
Neurology
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symptoms of dementia in the elderly

The symptoms of dementia mainly include: First, impaired memory function, where the patient’s memory loss is very noticeable. Initially, they may not remember recent events, and as the disease progresses, they may not remember past events, such as forgetting how many children they have or their children’s names. Second, it mainly involves symptoms of impairment in other cognitive areas, such as visual spatial dysfunction, manifesting as not being able to find the bathroom at home, getting lost after going out, and not being able to find the way back home. Additionally, the patient's ability to understand, calculate, and judge will also be significantly impaired, and they cannot master previously learned knowledge and skills. Third, in the late stages, some psychiatric symptoms appear, including visual and auditory hallucinations, and agitated behaviors such as hitting and cursing. Additionally, the patient may also experience some physical weakness, muscle atrophy, and incontinence.

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probability of senile dementia

Dementia primarily refers to Alzheimer's disease, which has a relatively high incidence rate. In China, among the elderly population over 65 years old, approximately 3% to 7% are affected; this rate can rise to over 20% among those over 85 years old. Suffering from dementia places a heavy burden on the patient, their family, and society. Initially, patients with dementia will experience a decline in memory function. As the condition progresses, there will be a decline in various cognitive functions. For example, spatial dysfunction might occur, such as getting lost on the way home, personality changes, and the emergence of psychiatric symptoms and other clinical manifestations.

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Written by Tang Bo
Neurology
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Mild manifestations of senile dementia

Mild dementia, especially in its early stages, often goes unnoticed by family members. The initial symptoms generally include being particularly forgetful. This particularly affects short-term memory; for example, a person might repeat what was just said or be repeatedly clumsy in daily tasks, sometimes losing keys or forgetting to turn off the stove while cooking. This might seem like a lack of concentration, but in reality, it is due to forgetfulness. Emotionally, individuals who were once lively might become indifferent or detached, sometimes showing signs of excitement or agitation. Behaviorally, there can be changes, such as previously generous individuals becoming stingy. Interests and hobbies that were once loved may no longer hold appeal, and individuals may become lethargic and less concerned with cleanliness and personal appearance.

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Written by Zhang Hui
Neurology
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Late-stage symptoms of senile dementia

Elderly dementia generally refers to Alzheimer's disease. This disease begins slowly and progressively worsens, with symptoms becoming increasingly severe. In the later stages of dementia, symptoms are numerous, mainly reflected in the following aspects: First, patients may exhibit significant personality changes. For example, a person who was originally gentle may become irritable and prone to aggressive behaviors such as hitting or yelling at others, and may even experience incontinence. Second, a patient's overall cognitive functions completely collapse, with a comprehensive decline in memory, as well as significant impairments in computational abilities, judgment, and comprehension. There are also problems with time orientation, with patients unable to distinguish between day and night. Additionally, patients may experience severe malnutrition, develop bedsores, and suffer from serious complications such as pulmonary infections and urinary tract infections.