Causes of Alzheimer's Disease in the Elderly

Written by Zhang Hui
Neurology
Updated on September 06, 2024
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The causes of dementia in the elderly are not currently completely clear. Dementia in the elderly is mainly divided into familial and sporadic types. Familial dementia shows autosomal dominant inheritance, which is caused by a gene mutation on chromosome 21 leading to the accumulation of some toxins, resulting in the death of neurons and causing dementia fundamentally due to genetic mutations. However, most cases of dementia are sporadic and do not have a clear family history. The mechanisms and reasons for disease onset are not particularly clear. Some believe that abnormalities in cerebral vascular function may lead to neuronal cell functional disorders, resulting in decreased ability to clear certain cell toxins, thus leading to neuronal apoptosis and death, and consequently impaired cognitive functions. In addition, factors such as oxidative stress, inflammatory mechanisms, excessive fatigue, and emergency stress may also cause cell death. Overall, the causes of dementia in the elderly are not particularly clear.

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Written by Zhang Hui
Neurology
1min 13sec home-news-image

Care measures for dementia in the elderly

Dementia in the elderly is the most common neurodegenerative disease in neurology, mainly referring to the irreversible death of neuronal cells caused by various reasons, which poses a significant clinical hazard and lacks effective treatment methods. Therefore, nursing measures become very important. The main nursing measures include, First, ensuring the patient's nutrition. In the later stages, elderly patients may have no regular diet and cannot take care of themselves. Therefore, ensuring sufficient energy intake and enough protein intake is very important. Malnutrition can easily lead to various complications, leading to the patient's death. Second, it's important to equip elderly people with commonly used contact numbers and addresses in their pockets to prevent them from getting lost and creating dangerous situations. Third, when elderly people are at home, it is crucial to keep the kitchen door closed to prevent them from turning on the gas and forgetting to turn it off. Fourth, patients with dementia are prone to lung infections after becoming bedridden. If bedridden, it is important to frequently turn them over and pat their back to prevent the onset of lung infections.

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Written by Zhang Hui
Neurology
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early signs of dementia

Dementia in the elderly, mainly referring to Alzheimer's disease, is primarily characterized by a significant decline in the patient's memory and learning abilities. Of course, there are some prodromal symptoms before the onset of dementia. For example, patients might show no clinical signs of cognitive impairment or only display very slight memory decline. Patients might exhibit mild impairment in memory, a decrease in the ability to learn and retain new information, and mild impairments in other cognitive areas such as attention, executive function, language skills, and visuospatial abilities. However, these impairments are very slight and can go unnoticed by family members. Moreover, these mild impairments do not affect the patient's basic daily life abilities and do not reach the level of dementia. Patients can live independently and manage their routine daily tasks, which are mainly some of the early signs of dementia.

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Written by Zhang Hui
Neurology
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probability of senile dementia

Dementia primarily refers to Alzheimer's disease, which has a relatively high incidence rate. In China, among the elderly population over 65 years old, approximately 3% to 7% are affected; this rate can rise to over 20% among those over 85 years old. Suffering from dementia places a heavy burden on the patient, their family, and society. Initially, patients with dementia will experience a decline in memory function. As the condition progresses, there will be a decline in various cognitive functions. For example, spatial dysfunction might occur, such as getting lost on the way home, personality changes, and the emergence of psychiatric symptoms and other clinical manifestations.

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Written by Zhang Hui
Neurology
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How is Alzheimer's treated?

The treatment of Alzheimer's disease mainly includes the following aspects. First, enhance care to prevent accidents. Patients with Alzheimer's may get lost, forget to turn off fires or gas, etc., so it is essential to strengthen care to prevent accidents. Second, encourage the elderly to read more books and newspapers and enhance learning, which can effectively slow down the progression. Third, have the elderly interact more with others and exercise more. This can strengthen their physical health and, to some extent, delay the development of Alzheimer's disease. Another aspect is drug treatment, which mainly includes acetylcholinesterase inhibitors and some NMDA receptor antagonists. These can improve the symptoms to some extent and enhance the quality of life. Additionally, in the later stages of Alzheimer's, some psychiatric symptoms such as visual hallucinations and aggressive behavior like hitting or yelling may occur. Appropriate atypical antipsychotic drugs can be administered for treatment.

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Written by Guan Yu Hua
Orthopedic Surgery
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Is spinal bifida prone to dementia?

Spina bifida is a common congenital malformation caused by incomplete closure of the vertebral canal during embryonic development. If the spina bifida is occult, it does not affect anything and does not cause dementia. If it is overt spina bifida, it can be diagnosed through physical examination, and confirmed with radiographic examination, CT, or MRI. Typically, the patient has a swelling along the midline of the back, which grows as they age. The cystic tension increases when the child cries, and may be accompanied by varying degrees of flaccid paralysis of the lower limbs and incontinence. Occult spina bifida generally has no symptoms and does not require intervention. However, overt spina bifida is best treated surgically, or if the occult spina bifida is accompanied by spinal cord tethering, then surgical treatment is recommended as it would be for all cases of overt spina bifida. In cases where the cyst wall is very thin and ruptured, emergency surgery is necessary and can be curative. For other cases, surgery within one to three months is optimal to prevent aggravation of the condition due to cyst rupture. Generally, adult patients with stable conditions in recent years may not need surgery.