Myasthenia Gravis

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Written by Liu Hong Mei
Neurology
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Can people with myasthenia gravis soak their feet?

Soaking in hot water can promote blood circulation, dilate blood vessels, improve local blood circulation in the lower limbs, promote metabolism, prevent thrombosis, and prevent muscle atrophy. In the early stages of myasthenia gravis, patients often experience limb discomfort, numbness, pain, blurred vision, and fatigue. In work and daily life, it is common to experience tiredness, memory loss, slow responses, and reluctance to be active. Soaking the feet can promote blood circulation and can improve local blood flow, which has a certain beneficial effect on myasthenia gravis. As the disease progresses, there is obvious fatigue and weakness in the skeletal muscles, especially after fatigue in the afternoon and evening, which is reduced in the morning or after rest.

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Written by Tang Bo
Neurology
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Myasthenia Gravis Best Treatment

The treatment of myasthenia gravis should also be individualized, specifically based on the actual condition of the patient. First and foremost, a clear diagnosis is essential. Once the diagnosis is confirmed, cholinesterase inhibitors can be used, but the dosage and frequency must be decided based on the patient's individual condition. Additionally, if the patient has a thymoma or thymic hyperplasia, a surgeon should determine whether surgical treatment is necessary. It is also necessary to consider whether to use steroids or plasmapheresis. In the event of a myasthenic crisis, symptomatic treatment should be provided according to the situation to maintain the patient's vital signs, and it is crucial to diagnose and treat early.

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Written by Shi De Quan
Neurology
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What are the side effects of taking steroid medication for myasthenia gravis?

The side effects of steroids in treating myasthenia gravis mainly include Cushing's syndrome characterized by specific facial and bodily features, weight gain, swelling in the lower legs, purple striae, tendency to bleed easily, poor wound healing, acne, and menstrual disorders. There could also be ischemic necrosis of the femoral or humeral heads, osteoporosis and fractures, primarily compressive vertebral fractures, as well as pathological fractures of the long bones, muscle weakness, muscle atrophy, and hypokalemia syndrome. Gastrointestinal irritation is common, primarily nausea and vomiting, as well as peptic ulcers or perforation, pancreatitis, and suppressed growth in children.

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Written by Xie Wen
Neurology
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Myasthenia Gravis Surgical Treatment

Myasthenia gravis is an autoimmune disease, with many patients also having a thymoma. The thymus is a very important immune organ in humans, and abnormal proliferation of the thymus can produce acetylcholine receptor antibodies. These antibodies circulate to the neuromuscular junction and participate in the antigen-antibody reaction, leading to the onset of myasthenia gravis. By removing the thymus, the initiating antigens of the patient's autoimmune response can be eliminated, reducing the involvement of T cells, B cells, and cytokines in the autoimmune response. This surgery is suitable for patients with thymic hyperplasia and high acetylcholine receptor antibody titers, or those with various types of myasthenia gravis with thymoma, as well as young women with generalized myasthenia gravis, and those who are dissatisfied with cholinesterase inhibitor treatment. About 70% of patients can experience symptom relief or complete recovery after surgery.

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Written by Tang Li Li
Neurology
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Can severe myasthenia gravis be cured by massage?

Myasthenia Gravis cannot be treated through massage, as it is an acquired autoimmune disease primarily caused by damage to the acetylcholine receptors at the neuromuscular junction. Treatment involves the use of immunosuppressive medications such as corticosteroids, immunosuppressants, and azathioprine. Typically, high doses of corticosteroids are administered to suppress the immune-inflammatory response and reduce the production of acetylcholine receptor antibodies, allowing a sufficient number of acetylcholine receptors to be preserved. Additionally, acetylcholinesterase inhibitors can be used to decrease the breakdown of acetylcholine and increase its concentration in the synaptic gap, thus promoting impulse transmission at the neuromuscular junction and improving symptoms of muscle weakness. The most commonly used medications in standard treatment include pyridostigmine, and corticosteroids such as methylprednisolone or prednisolone. (Please use medications under the guidance of a doctor)

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Written by Liu Hong Mei
Neurology
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Is myasthenia gravis an autoimmune disease?

Myasthenia gravis is an autoimmune disease that primarily affects the neuromuscular junction, leading to abnormalities in acetylcholine receptors. This can cause weakness in some or all skeletal muscles, which easily fatigues, particularly after activity or exertion, with symptoms worsening. Symptoms can be alleviated after rest or treatment with cholinesterase inhibitors. As an autoimmune disease, myasthenia gravis often co-occurs with other autoimmune disorders such as hyperthyroidism, thyroiditis, systemic lupus erythematosus, and rheumatoid arthritis. Symptoms of myasthenia gravis typically lessen in the morning and worsen after activity, showing a pattern of being lighter in the morning and heavier in the evening.

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Written by Zhang Hui
Neurology
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What medicine should be taken for myasthenia gravis?

Myasthenia gravis is a type of neurological immunological disease in neurology, mainly caused by a disorder of the body's own immune function. Patients in the body will produce antibodies against acetylcholine receptors, thus affecting the transmission of nerve impulses at the neuromuscular junction. For this disease, the following medications are generally prescribed: The first type of medication is a cholinesterase inhibitor, which can increase the amount of acetylcholine at the neuromuscular junction, thereby effectively improving clinical symptoms. The second type of medication is corticosteroids, because this disease is caused by an abnormal inflammatory response. Therefore, taking corticosteroids can suppress the inflammatory response. Treatment generally starts with a small dose and gradually increases, maintaining for a period before gradually tapering off. It may also be necessary to take other immunosuppressants. (Please take the medication under the guidance of a doctor)

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Written by Zhang Hui
Neurology
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Acupuncture treatment for myasthenia gravis

Patients with myasthenia gravis suffer from a systemic autoimmune disease, primarily affecting the neuromuscular junctions, which leads to corresponding clinical manifestations. The essence of the disease is caused by immune dysfunction, where the body produces specific antibodies that affect the transmission of impulses. Patients typically experience general weakness, double vision, drooping eyelids, and in severe cases, weakened respiratory muscles leading to respiratory paralysis. The treatment of myasthenia gravis mainly involves medication, including corticosteroids, immunoglobulins, acetylcholinesterase inhibitors, and other immunosuppressants. Additionally, there are some newer drugs that modulate the immune system. Acupuncture treatment, as an important method of traditional Chinese medicine, can also be used in the management of myasthenia gravis, primarily to improve the patients' resistance, enhance physical constitution, and play a significant role in preventing complications and reducing the dosage of other medications. (Specific medications should be administered under the guidance of a physician.)

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Written by Zhang Hui
Neurology
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Early symptoms of myasthenia gravis

Myasthenia gravis is a disease of the neuromuscular junction and also an autoimmune disease, caused by a dysfunction in the patient's immune system. Early symptoms of myasthenia gravis may include mild general fatigue, which can be relieved by rest, and may not be particularly concerning to the individual. Some patients may initially exhibit slight ptosis and occasional double vision as clinical symptoms, which they might not take very seriously either. As the disease progresses, the symptoms become more severe, such as noticeable ptosis, double vision, slurred speech, difficulty swallowing, and even potential weakness of the respiratory muscles, leading to respiratory failure.

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Written by Zhang Hui
Neurology
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Causes of myasthenia gravis

Myasthenia gravis is a type of neurological autoimmune disease. The cause and mechanism of this disease are primarily due to disorders in the immune function of the body. Antibodies are produced in the body which attack the acetylcholine receptors at the neuromuscular junction, leading to the failure of nerve impulses being transmitted to the muscles. This results in the clinical symptoms observed. Many patients may have thymic abnormalities, such as thymomas. Treatment of this disease involves the use of cholinesterase inhibitors and suppression of these abnormal immune responses, typically requiring the use of corticosteroids.