Causes of myasthenia gravis

Written by Zhang Hui
Neurology
Updated on February 24, 2025
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Myasthenia gravis is a type of neurological autoimmune disease. The cause and mechanism of this disease are primarily due to disorders in the immune function of the body. Antibodies are produced in the body which attack the acetylcholine receptors at the neuromuscular junction, leading to the failure of nerve impulses being transmitted to the muscles. This results in the clinical symptoms observed. Many patients may have thymic abnormalities, such as thymomas. Treatment of this disease involves the use of cholinesterase inhibitors and suppression of these abnormal immune responses, typically requiring the use of corticosteroids.

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Written by Zhang Hui
Neurology
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incidence of myasthenia gravis

Myasthenia gravis is a disease of the neurology department. Its incidence rate is around one in one hundred thousand. The prevalence rate is around fifty per one hundred thousand. In China, the incidence rate in the south is slightly higher than in the north. This is an autoimmune disease of the nervous system. Generally, it is due to the production of some abnormal antibodies. These antibodies cause dysfunction in synaptic transmission at the neuromuscular junction, leading to corresponding clinical manifestations in patients. For example, extreme fatigue after physical activity that can only be alleviated by rest. Patients may also exhibit clinical symptoms such as ptosis, diplopia, and difficulty swallowing, and in severe cases, even respiratory muscle weakness may occur, requiring the use of a ventilator. This disease can occur at any age, affecting children as well as elderly men aged 70 to 80. Therefore, correct understanding of this disease and timely treatment are very important.

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Written by Zhang Hui
Neurology
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Does myasthenia gravis require hospitalization?

Myasthenia Gravis is a type of neuroimmune disease within the field of neurology which fundamentally stems from issues with the patient's own immune function. Whether hospitalization is necessary depends critically on the severity of the disease. If Myasthenia Gravis manifests only as ocular symptoms, such as ptosis and double vision, hospitalization is generally not necessary. It is important to take certain medications, primarily cholinesterase inhibitors and corticosteroids, but regular outpatient follow-ups are essential. However, if Myasthenia Gravis is generalized, with noticeable whole-body weakness, particularly if accompanied by swallowing difficulties and coughing while drinking, hospitalization is required. If a myasthenic crisis occurs, presenting with respiratory muscle weakness and breathing difficulties, hospitalization is certainly needed, and admission to the ICU might be necessary.

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Written by Zhang Hui
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Myasthenia Gravis Clinical Manifestations

Myasthenia gravis is a type of immunological disease of the nervous system that belongs to neurology. The common clinical manifestations include the following aspects. First, some patients may experience ptosis, where they cannot open their eyes. It usually starts on one side and may also involve abnormal eye movements, such as difficulty in moving the eyes to the left or right, leading to double vision and other clinical manifestations. Second, some patients may experience dysphagia, such as difficulty swallowing, choking on water, and speech articulation disorders. Third, some patients may experience weakness in their limbs, especially an inability to perform strenuous physical activities, such as climbing stairs, which can be significantly affected. These clinical manifestations usually show a pattern of being less severe in the morning and more severe in the evening.

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Written by Zhang Hui
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What department is myasthenia gravis under?

Myasthenia gravis, this disease definitely requires registration with the Department of Neurology as it is a relatively common disease in neurology, and doctors in other departments are not particularly familiar with this disease, let alone diagnosis and treatment. Myasthenia gravis is an immune disease of the nervous system, and patients may experience generalized fatigue, which can be alleviated after rest. It is characterized by clinical symptoms that are lighter in the morning and more severe in the evening. Additionally, symptoms such as ptosis, double vision, and even some difficulties in swallowing and unclear speech, known as bulbar paralysis, may occur. This disease requires a thorough chest CT scan, as many patients have an associated thymoma. Furthermore, an electromyography examination is needed to check for antibodies related to myasthenia gravis, which is also important for guiding further treatment.

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Written by Tang Bo
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myasthenia gravis-related antibodies

Most cases of myasthenia gravis are mediated by acetylcholine receptor antibodies, involving cell-mediated immunity with complement, generally affecting the neuromuscular junction and causing a neuromuscular transmission disorder. This results in an acquired autoimmune disease of muscle weakness. However, a small number of patients with myasthenia gravis are mediated by muscle-specific kinase antibodies or low-density lipoprotein receptor-related protein 4 antibodies. Its main clinical manifestations include skeletal muscle weakness, fatigue, worsening with activity, and significant alleviation or reduction of symptoms after rest and the use of acetylcholinesterase inhibitors. Additionally, the disease can occur at any age, with females being more affected than males before the age of 40. Between 40 and 50 years old, the incidence rates between males and females are comparable, but after 50 years of age, the incidence rate in males is higher than in females.