Myasthenia Gravis Surgical Treatment

Written by Xie Wen
Neurology
Updated on March 20, 2025
00:00
00:00

Myasthenia gravis is an autoimmune disease, with many patients also having a thymoma. The thymus is a very important immune organ in humans, and abnormal proliferation of the thymus can produce acetylcholine receptor antibodies. These antibodies circulate to the neuromuscular junction and participate in the antigen-antibody reaction, leading to the onset of myasthenia gravis. By removing the thymus, the initiating antigens of the patient's autoimmune response can be eliminated, reducing the involvement of T cells, B cells, and cytokines in the autoimmune response. This surgery is suitable for patients with thymic hyperplasia and high acetylcholine receptor antibody titers, or those with various types of myasthenia gravis with thymoma, as well as young women with generalized myasthenia gravis, and those who are dissatisfied with cholinesterase inhibitor treatment. About 70% of patients can experience symptom relief or complete recovery after surgery.

Other Voices

doctor image
home-news-image
Written by Zhang Hui
Neurology
1min 7sec home-news-image

incidence of myasthenia gravis

Myasthenia gravis is a disease of the neurology department. Its incidence rate is around one in one hundred thousand. The prevalence rate is around fifty per one hundred thousand. In China, the incidence rate in the south is slightly higher than in the north. This is an autoimmune disease of the nervous system. Generally, it is due to the production of some abnormal antibodies. These antibodies cause dysfunction in synaptic transmission at the neuromuscular junction, leading to corresponding clinical manifestations in patients. For example, extreme fatigue after physical activity that can only be alleviated by rest. Patients may also exhibit clinical symptoms such as ptosis, diplopia, and difficulty swallowing, and in severe cases, even respiratory muscle weakness may occur, requiring the use of a ventilator. This disease can occur at any age, affecting children as well as elderly men aged 70 to 80. Therefore, correct understanding of this disease and timely treatment are very important.

doctor image
home-news-image
Written by Zhang Hui
Neurology
1min 7sec home-news-image

What should I do if myasthenia gravis is accompanied by a fever?

Patients with myasthenia gravis are most afraid of developing a fever, as a fever may indicate an infection, especially a bacterial infection. If a bacterial infection occurs, it can easily trigger a myasthenic crisis. The patient may experience weakness in breathing and even respiratory failure, which can be life-threatening. Therefore, it is essential to address the situation promptly. The recommended approach when a fever occurs is as follows: First, quickly determine the cause of the fever, complete routine blood tests, calcitonin, and other relevant assays to confirm if it is caused by a bacterial infection. Second, symptomatically manage the fever, possibly using antipyretic medications. Third, if it is a bacterial infection, it is crucial to promptly administer a significant amount of effective antibiotics to treat it. Controlling the bacterial infection can prevent the progression of myasthenia gravis to a more severe state. (Note: Medication should be used under the guidance of a doctor.)

doctor image
home-news-image
Written by Zhang Hui
Neurology
42sec home-news-image

Early symptoms of myasthenia gravis

Myasthenia gravis is a disease of the neuromuscular junction and also an autoimmune disease, caused by a dysfunction in the patient's immune system. Early symptoms of myasthenia gravis may include mild general fatigue, which can be relieved by rest, and may not be particularly concerning to the individual. Some patients may initially exhibit slight ptosis and occasional double vision as clinical symptoms, which they might not take very seriously either. As the disease progresses, the symptoms become more severe, such as noticeable ptosis, double vision, slurred speech, difficulty swallowing, and even potential weakness of the respiratory muscles, leading to respiratory failure.

doctor image
home-news-image
Written by Zhang Hui
Neurology
59sec home-news-image

Myasthenia Gravis should be seen by which department?

Myasthenia gravis is considered a neurological disease, so if myasthenia gravis is suspected, it is advisable to consult a neurologist. Neurologists are quite familiar with myasthenia gravis, especially those who specialize in its research. They are particularly knowledgeable about diagnosing and treating this disease. Myasthenia gravis is an autoimmune disease of the nervous system that primarily affects the neuromuscular junction, causing muscle weakness in the body. The symptoms typically worsen towards the evening and include pathological fatigue. Muscle weakness usually improves after rest. Clinical manifestations also include ptosis, double vision, difficulty swallowing, and coughing while drinking. Neurologists may prescribe various diagnostic tests such as electromyography, chest CT scans, and tests for acetylcholine receptor antibodies.

doctor image
home-news-image
Written by Zhang Hui
Neurology
1min 5sec home-news-image

Does myasthenia gravis cause sensitivity to cold?

Patients with myasthenia gravis tend to be sensitive to cold, mainly due to the following factors: Firstly, patients with myasthenia gravis generally experience overall weakness and have very limited physical activity, making their physique rather frail. Patients with a weak physique are definitely more susceptible to colder environments. Secondly, patients with myasthenia gravis have lower resistance to diseases and often take immunosuppressants for a long time, making them highly susceptible to respiratory and lung infections. In cold conditions, some viruses can exploit this weakness, leading to exacerbated lung and respiratory infections, which is another major reason why patients with myasthenia gravis are sensitive to cold. Thirdly, myasthenia gravis is an autoimmune disease that leads to immune dysfunction. This immune dysfunction makes patients particularly sensitive to cold stimuli. In a cold environment, their immune function may become even more disordered, contributing further to their sensitivity to cold.