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He Li Fang
Hematology
About me
Loudi Central Hospital, Department of Hematology, Attending Physician.
Proficient in diseases
Specializes in the diagnosis and treatment of common diseases in hematology.
Voices
Mediterranean anemia's blood routine manifestations
The hematological manifestations of thalassemia, including those of silent gene carriers, generally show normal complete blood counts. In thalassemia and mild thalassemia, hemoglobin levels are normal or slightly decreased. Patients with Hemoglobin H disease have hemoglobin levels between 70-100 grams per liter. In cases of Hemoglobin Bart's hydrops fetalis syndrome and severe thalassemia, hemoglobin levels are typically below 50 grams per liter, falling into the category of severe anemia, requiring regular blood transfusions for survival. Their MCV, MCH, and MCHC are significantly decreased. Blood smears may reveal anisocytosis and poikilocytosis including target cells, and even nucleated red cells, with a marked increase in reticulocytes. Typically, the white blood cell count remains normal for such patients, although the platelet count may be slightly elevated. During periods of increased spleen activity, there may be a reduction in both white blood cells and platelets. These are the hematologic features observed in different thalassemia patients.
Iron deficiency anemia is what type of anemia?
Iron deficiency anemia refers to the anemia that occurs when the body's stored iron is depleted and cannot meet the needs for normal red blood cell production. Before the production of red blood cells is limited, the body's stored iron has already been exhausted. However, at this stage, the routine blood tests may not yet show obvious signs of anemia; this condition is then referred to as iron deficiency. The characteristics of iron deficiency anemia include a lack of stainable iron in the bone marrow and other tissues, as well as reduced serum ferritin and transferrin saturation, presenting as typical microcytic hypochromic anemia. Therefore, iron deficiency anemia is a type of microcytic hypochromic anemia and is classified according to the level of marrow proliferation as a hyperproliferative anemia.
Chronic granulocytic leukemia symptoms
The clinical symptoms of chronic myeloid leukemia can be divided into two phases: 1. During the chronic phase, the earliest subjective symptoms include fatigue, dizziness, and abdominal discomfort. Other symptoms may also appear such as general malaise, decreased endurance, and nausea. Some patients may exhibit signs of increased basal metabolism, such as sweating, weight loss, palpitations, and nervousness. As the disease progresses, patients may experience enlargement of the liver and spleen. An enlarged spleen can cause abdominal bloating, discomfort in the upper left abdomen, and a feeling of fullness after eating. In a few cases, bleeding may occur in the early stages. In female patients, excessive menstruation is common, and while bone pain and joint pain are less common at initial diagnosis, they can also occur. 2. During the accelerated phase, patients often exhibit unexplained low-grade fever, fatigue, lack of appetite, night sweats, and increased weight loss. These symptoms are accompanied by rapid enlargement of the spleen causing discomfort and fullness, sudden swelling of lymph nodes, clear sternal tenderness, and osteolytic changes in bones leading to bone pain. Anemia also progressively worsens. Once patients enter the blast crisis phase, they may show extramedullary infiltration symptoms such as skin nodules, testicular infiltration, abnormal penile erections, and the appearance of green tumors in the eye sockets, among other serious complications.
Causes of Iron Deficiency Anemia
There are many reasons for iron deficiency anemia, which we can categorize into several aspects. The first aspect is a decrease in iron intake, including diet, meaning insufficient dietary intake. The second aspect is decreased absorption, such as the absence of a target organ for absorption or the lack of stomach acid affecting its absorption efficacy. The second aspect refers to excessive loss, most commonly chronic gastrointestinal bleeding, such as in patients with tumors, duodenal ulcers, gastric ulcers, gastritis, ulcerative colitis, a parasitic infection with hookworms, as well as hemorrhoids, and arteriovenous malformations, all of which can cause gastrointestinal bleeding leading to increased iron loss. Excessive menstrual flow in female patients, multiple blood donations, and multiple pregnancies can all lead to iron deficiency. These are the various causes related to iron deficiency.
What are the symptoms of iron deficiency anemia?
Iron deficiency anemia is a type of anemia that exhibits common symptoms found in all anemia patients. It is characterized by a range of clinical symptoms caused by oxygen deficiency in tissue organs due to a lack of blood in the body. Common symptoms include dizziness, headaches, fatigue, shortness of breath and palpitations after activity, easy fatigability, difficulty concentrating, and decreased memory. Some patients may also experience blurred vision, ringing in the ears, and in severe cases, fainting, transient darkening of vision, and even arrhythmias. Because iron deficiency anemia is also accompanied by iron deficiency, it presents a range of clinical symptoms specific to iron deficiency, including pica, angular cheilitis, glossitis, unusual tongue conditions, decreased appetite, and even constipation among other symptoms.
Symptoms of iron deficiency anemia
The clinical manifestations of iron deficiency anemia consist of symptoms due to the anemia itself, specific manifestations of iron deficiency, and the underlying diseases causing the iron deficiency. The onset of anemia is often insidious, with some patients progressing very slowly. Initially, patients can adapt well to daily life and continue with their work, making it difficult to detect. It is usually not until the anemia becomes moderate to severe and symptoms become apparent that it is discovered. Common symptoms of anemia include dizziness, headaches, weakness, easy fatigue, palpitations, and shortness of breath after activity. Some patients might also experience a decline in memory and suffer from tinnitus and blurred vision. Some affected children may exhibit delayed growth and development or even abnormal behaviors, which can manifest as irritability, restlessness, inattention in class, and declining academic performance. A few patients may develop pica, a specific manifestation of iron deficiency anemia. Additionally, some patients might suffer from angular cheilitis, glossitis, and even atrophy of the tongue papillae. Severe cases can experience transient blindness and fainting, hence it is crucial to seek medical attention for iron deficiency anemia at the earliest.
What is the fastest way to treat iron deficiency anemia?
Iron deficiency anemia is a type of anemia caused by a lack of storage iron in the body, affecting the synthesis of hemoglobin. It is characterized by a lack of available iron in tissues and organs such as bone marrow, liver, and spleen, with decreased serum iron concentration, transferrin saturation, and serum ferritin levels. Typically, iron deficiency anemia presents as microcytic hypochromic anemia. Iron, as one of the essential trace elements in the human body, is contained in all functioning cells and is broadly involved in metabolic processes within the body. Therefore, the treatment principle for iron deficiency anemia involves replenishing sufficient iron until normal iron stores are restored and addressing the underlying causes that led to the iron deficiency to effectively and quickly replenish iron. Oral iron supplements are the preferred treatment option for iron deficiency anemia, such as ferrous sulfate, ferrous succinate, and iron dextran which are effective oral iron agents.
What is leukemia?
Leukemia is a malignant tumor of the hematopoietic system that originates from hematopoietic stem/progenitor cells. It involves leukemia cells that have proliferative and survival advantages, proliferating and accumulating uncontrollably in the body, gradually replacing normal hematopoiesis to form pathological hematopoiesis. Furthermore, it invades other organs and systems, leading to symptoms such as anemia, bleeding, and infections, which eventually cause death. The incidence of leukemia is 4.8/100000-7.1/100000 in males and 3.2/100000-4.6/100000 in females, with significant variations in incidence, mortality rates, and distribution among different types of leukemia and various regions and ethnic groups. Early on, it was recognized that leukemia is not an inflammation, and the views that leukemia is caused by a lack of certain substances have been proven incorrect. Currently, it is understood that the causative factors of leukemia are related to infections, radiation, chemical agents, lifestyle, and genetics.
Can thalassemia be inherited by children?
Thalassemia, originally known as Mediterranean anemia or thalassemia, was named due to the early discovered cases predominantly among the Mediterranean coastal populations. However, the disease is widespread in many regions around the world, with Southeast Asia being one of the high-prevalence areas. In China, it is more commonly seen in Guangdong, Guangxi, and Sichuan, and there are also scattered cases in the provinces and regions south of the Yangtze River, while it is less common in the north. It is caused by a hereditary defect in the globin gene, leading to the absence or insufficiency of one or more globin chains in hemoglobin, resulting in anemia. This pathological state is called thalassemia. Due to the complex diversity of genetic defects, the types and quantities of the missing globin chains, as well as clinical symptoms, can vary. Thus, thalassemia encompasses a group of diseases. Being a genetic disorder, Mediterranean anemia can be inherited by children.
Which department should I go to for iron deficiency anemia?
The formed elements in the blood include red blood cells, white blood cells, and platelets, which play important roles in cellular metabolism, defense, and hemostasis, respectively. Among them, anemia falls under the category of red blood cell diseases. Iron-deficiency anemia refers to a condition where the body's iron stores are depleted, failing to meet the needs for normal red blood cell production. Before the production of red blood cells is restricted, the body's iron stores are already depleted, but anemia has not yet occurred, a condition we call iron deficiency, also known as the subclinical iron deficiency period clinically. Iron-deficiency anemia is a common red blood cell disease and falls under the category of hematology. Therefore, patients with iron-deficiency anemia should consult a specialist in hematology.