The clinical symptoms of chronic myeloid leukemia can be divided into two phases: 1. During the chronic phase, the earliest subjective symptoms include fatigue, dizziness, and abdominal discomfort. Other symptoms may also appear such as general malaise, decreased endurance, and nausea. Some patients may exhibit signs of increased basal metabolism, such as sweating, weight loss, palpitations, and nervousness. As the disease progresses, patients may experience enlargement of the liver and spleen. An enlarged spleen can cause abdominal bloating, discomfort in the upper left abdomen, and a feeling of fullness after eating. In a few cases, bleeding may occur in the early stages. In female patients, excessive menstruation is common, and while bone pain and joint pain are less common at initial diagnosis, they can also occur. 2. During the accelerated phase, patients often exhibit unexplained low-grade fever, fatigue, lack of appetite, night sweats, and increased weight loss. These symptoms are accompanied by rapid enlargement of the spleen causing discomfort and fullness, sudden swelling of lymph nodes, clear sternal tenderness, and osteolytic changes in bones leading to bone pain. Anemia also progressively worsens. Once patients enter the blast crisis phase, they may show extramedullary infiltration symptoms such as skin nodules, testicular infiltration, abnormal penile erections, and the appearance of green tumors in the eye sockets, among other serious complications.