The treatment of depression in clinical settings primarily utilizes pharmacotherapy, psychotherapy, and physical therapy.

Pharmacotherapy, as the first-line treatment for depression, mainly relies on selective serotonin reuptake inhibitors such as paroxetine, fluoxetine, sertraline, escitalopram, venlafaxine, and duloxetine. Adequate dosages and treatment duration with a systematic approach are essential when using pharmacotherapy.

Secondly, psychotherapy. The main psychotherapeutic approaches include cognitive-behavioral therapy, psychoanalytic therapy, and interpersonal therapy, which aim to improve the patient's irrational cognitions and rebuild their cognitive framework.

Thirdly, physical therapy. In clinical practice, physical therapy mainly encompasses electroconvulsive therapy and transcranial magnetic stimulation, both of which can yield significant therapeutic outcomes.

(Specific medications should be used under the guidance of a physician.)