Relapse in patients with depression is a relatively common issue in clinical practice. Large-scale studies have found that even with systematic, standardized treatment with sufficient dosage and duration of antidepressant medications, still 15% of patients do not achieve clinical recovery. Even with persistent standardized treatment, the relapse rate remains at 20%. If treatment is discontinued, the relapse rate can rise to as high as 85%. For patients who have recovered, there is still a 20% chance of relapse within six months. 50% of patients relapse within two years after their first episode. Therefore, the relapse rate is higher in patients over the age of 45. Thus, depression is characterized by a high rate of relapse, yet it is also highly treatable. Therefore, during the course of pharmacological treatment, psychological and physical therapies should be concurrently employed as adjunctive treatments to improve cure rates and reduce the likelihood of relapse.