Systemic lupus erythematosus (SLE) kidney is a chronic autoimmune disease with multi-organ damage that occurs systemically. This disease is common in women of childbearing age and is most frequently characterized by facial rashes. It can also present with fever, hair loss, and even edema of both lower limbs and hypoalbuminemia. As an autoimmune disease, it cannot be cured and can only be managed with medications. Treatment aims to stabilize the condition and gradually reduce the medication dosage to the minimum necessary to maintain the condition and prevent it from becoming active, thus delaying damage to other organs. Systemic lupus erythematosus involves multiple systems, with the kidneys being the most susceptible, requiring formal medical treatment to prevent complications in the organs.