Breast cancer chemotherapy regimen

Written by Gong Chun
Oncology
Updated on September 06, 2024
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Breast cancer chemotherapy regimen. Thus, chemotherapy occupies a very important position in the treatment of breast cancer. The commonly used chemotherapy drugs in breast cancer treatment include alkylating agents, such as cyclophosphamide; antimetabolites like fluorouracil, methotrexate, gemcitabine, and capecitabine; anthracyclines, such as doxorubicin and others. In recent years, taxanes, particularly docetaxel, have been used more frequently. Other drugs include mitomycin and cisplatin, among others. However, the specific chemotherapy regimen for breast cancer should be assessed by a professional oncologist. The regimen should consider the pathological stage, pathological type, whether surgery was performed, whether the surgery completely removed the tumor, lymph node metastasis, and other factors to devise a suitable chemotherapy plan. Therefore, it is possible that each individual might have a regimen that is specifically suited to their situation, and not all regimens are suitable for everyone.

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Written by Gong Chun
Oncology
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How does one get breast cancer?

How is breast cancer caused? Regarding the causes of breast cancer, the primary factor should be family history. If a first-degree relative has breast cancer, then the likelihood of developing breast cancer increases. The second factor is reproductive factors; for instance, if the age at menarche is quite young, menopause age is relatively late, menstrual cycles are short, there is no childbirth or the age at first full-term pregnancy is older, there are fewer childbirths, and there is a lack of breastfeeding, then the incidence of breast cancer is also higher. The third factor involves hormones, possibly related to endogenous hormones or exogenous hormones, such as those mainly associated with oral contraceptives used externally. The fourth major point is a high-fat diet, or habits like drinking alcohol, smoking, and a diet low in vitamins, which may increase the risk of breast cancer. The fifth point involves other factors, such as exposure to significant amounts of ionizing radiation, chemicals from cancer drugs, lack of physical exercise, and occupations, such as working in the beauty industry or pharmaceutical manufacturing, etc., which may also increase the chances of developing breast cancer.

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Written by Yan Chun
Oncology
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Symptoms of male breast cancer

The clinical symptoms of male breast cancer are generally similar to those of females, mainly presenting as painless, progressive enlargement of breast lumps. These breast lumps usually occur under the areola, and some patients may experience nipple inversion or abnormal nipple discharge. Many breast lumps tend to have unclear boundaries with surrounding tissues and often adhere to the skin or chest muscles. Many patients with male breast cancer experience metastasis to the axillary lymph nodes, causing the metastatic lymph nodes to enlarge and become painful, local lymphatic drainage obstruction, and causing local upper limb swelling and pain. Moreover, some male breast cancer cases have metastasized to the lungs, presenting clinically with symptoms such as coughing and chest pain related to the respiratory system. Some patients with male breast cancer have liver metastasis, clinically presenting with pain in the liver area, decreased appetite, and abnormal coagulation functions.

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Written by Lin Yang
Breast Surgery
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early symptoms of breast cancer

60% of early-stage breast cancer presents as a lump, most commonly in the upper outer quadrant. The primary symptoms include a painless, solitary, small lump that is hard, uneven in surface, irregular in shape, and not clearly demarcated from surrounding tissues. The lump is hard to move within the breast, indicating adhesion to the surrounding tissue. The skin over the lump may show signs of redness, swelling, indentation, orange peel-like texture, dimpling, and ulceration. Sometimes, there may also be nipple discharge, typically bloody, and early-stage enlargement of the axillary lymph nodes can occur.

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Written by Zhang Chao Jie
Breast Surgery
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Breast cancer surgical methods

There are many surgical methods for breast cancer, but specifically, they are related to the stage of the disease. Generally speaking, the surgical methods for breast cancer include the following types: The first type is the modified radical mastectomy, which is the most traditional and has the broadest scope of excision. This often involves the complete removal of the breast, and the axilla may be cleared, or a sentinel lymph node biopsy may be performed instead, which is a possibility. The second type of breast cancer surgery is the best, used for early-stage breast cancer, which can preserve the breast, known as breast-conserving surgery. The third method of surgery involves removing all the glandular tissue inside the breast while preserving the skin, nipple, and areola complex, and then reconstructing the breast by placing an implant.

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Written by Fan Hong Qiao
Breast Health Department
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What is invasive breast cancer?

Invasive breast cancer is the most common tumor in women, accounting for 22% of all malignant tumors in females. Invasive breast cancer refers to a malignant tumor where cancer cells have broken through the basement membrane of the breast ducts or lobular alveoli and invaded the interstitium. The vast majority of invasive breast cancers are adenocarcinomas, originating from the epithelial cells of the breast parenchyma, especially from the terminal duct lobular units. Its characteristics include the tumor's infiltration into adjacent tissues and a marked tendency for distant metastasis.