How is rheumatoid arthritis diagnosed?

Written by Yang Ya Meng

Rheumatology

Updated on February 10, 2025

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Rheumatoid arthritis examinations include blood tests and imaging studies.

The blood tests include complete blood count, erythrocyte sedimentation rate, rheumatoid factor, C-reactive protein, anti-streptococcal antibodies, ANA, anti-CCP antibodies, and anti-AKA antibodies.

Imaging studies involve X-ray examinations of the hand joints. If the patient has significant increases in erythrocyte sedimentation rate and C-reactive protein, positive CCP and AKA antibodies, and the X-rays show bone destruction, then rheumatoid arthritis can be considered as a diagnosis.

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Rheumatoid arthritis symptoms

Rheumatoid arthritis is categorized as an autoimmune disease and is a chronic autoimmune condition that is destructive to joints. It is primarily characterized by symmetric polyarthritis, with clinical manifestations varying significantly among individuals. Most cases begin gradually, initially presenting with symmetrical pain and swelling in the wrists. This often accompanies morning stiffness, fatigue, low-grade fever, muscle pain, or weight loss. In a minority of cases, the onset is more abrupt, with typical clinical manifestations appearing within a few days, including joint dysfunction, morning stiffness, and joint pain and swelling. Joint deformity is a later manifestation of the disease, indicating that the disease was not well-controlled, leading to joint damage.

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Can rheumatoid arthritis be cured?

Rheumatoid arthritis is a chronic autoimmune disease characterized by systemic damage to multiple joints with an unclear cause. Thus, it cannot be cured, meaning it cannot be completely healed. Treatment can only alleviate joint pain and morning stiffness through medication, delay the onset of complications, reduce bone damage, decrease disability rates, and improve quality of life. This is the comprehensive purpose of treatment. Therefore, early diagnosis and standardized treatment of this disease are essential to prevent joint deformities and to maintain quality of life.

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What medicine is used for rheumatoid arthritis?

First, rheumatoid arthritis is an autoimmune disease and a chronic condition that cannot be cured. The primary goal of treatment is to alleviate symptoms, delay complications, improve quality of life, and reduce disability through conventional drug therapies. Treatment methods include general treatment and medication. General treatment consists of functional exercise and lifestyle considerations, such as avoiding cold water and raw, cold foods, and emphasizing the importance of exercise. Additionally, the first-line drug treatments include nonsteroidal anti-inflammatory drugs and disease-modifying antirheumatic drugs (DMARDs), with traditional DMARDs being the current preferred and anchor treatment option.

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The difference between osteoarthritis and rheumatoid arthritis

In everyday life, many patients confuse osteoarthritis with rheumatoid arthritis, but these two diseases are indeed very distinct. Generally speaking, osteoarthritis is mostly caused by hyperplastic arthritis due to trauma or, in some cases, osteoarthritis resulting from overuse, The characteristic of osteoarthritic pain is that it is related to activity. The more a joint affected by arthritis moves, and the greater the overuse, the more severe the pain becomes. When resting, the pain in that joint will decrease, However, rheumatoid arthritis is different and has clear distinctions from osteoarthritis. Rheumatoid arthritis typically affects the small joints of the limbs, usually occurs symmetrically, and rarely affects only one limb. Once it occurs, it generally affects other parts too, appearing in both hands or both feet. These small joints are usually the first to be affected, with symptoms presenting symmetrically, and there is significant morning stiffness; that is, joints are stiff in the morning, Furthermore, rheumatoid arthritis can cause pain at rest or pain during inactivity, and nocturnal pain does not necessarily correlate with activity. Sometimes, pain may intensify after rest or during the night, and sometimes, physical activity may actually alleviate the pain. Thus, this symptom is a primary distinguishing feature from osteoarthritis. Understanding these points, the differences between osteoarthritis and rheumatoid arthritis can basically be mastered.

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Is joint pain rheumatoid arthritis?

Firstly, it should be noted that there are many causes of joint pain in clinical practice, and it is not necessarily caused by rheumatoid arthritis. Of course, rheumatoid arthritis can also cause joint pain in patients. In addition, there are some other reasons, for example, local joint bacterial infection in patients can also cause joint pain. Furthermore, joint injuries leading to fractures, dislocations, soft tissue damage, ligament injuries, and meniscus injuries can also cause joint pain. Additionally, the presence of osteoarthritis or gouty arthritis can similarly lead to joint pain in patients.