Difference between early-stage and mid-stage gallbladder cancer

Written by Liu Wu Cai
Hepatobiliary Surgery
Updated on December 01, 2024
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For gallbladder cancer, its staging is mainly based on the size of the tumor and whether there are metastases to other parts of the body, including lymph node metastases. In early-stage gallbladder cancer patients, the tumor is generally small and there are no metastases to other parts of the body. At this stage, patients typically do not show specific symptoms.

Additionally, for patients with mid-stage gallbladder cancer, they may experience discomfort or dull pain in the upper right abdomen, and may also experience weight loss, possibly even developing cachexia. Therefore, gallbladder cancer patients can undergo surgical removal and a pathological examination can provide a better assessment of the pathological stage, leading to a better treatment plan.

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Written by Li Hu Chen
Imaging Center
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Can cholecystitis be detected by color ultrasound?

If there is gallbladder cancer, usually an ultrasonography of the liver and gallbladder or the upper abdomen can detect it. Conditions such as gallbladder cancer or liver cancer are often initially discovered and diagnosed through ultrasound. Of course, the final confirmation of diagnosis is usually achieved through pathological examination after surgery. However, in terms of initial diagnosis, it is very common to identify these conditions through ultrasound. Gallbladder cancer typically presents certain characteristic changes, such as obvious thickening of the gallbladder wall, extensive thickening including sclerosis, and significant soft tissue mass growth extending to and adhering to the liver, which are strong indicators of gallbladder cancer. Additionally, a large polyp may be seen inside the gallbladder, and surgical removal at this stage may diagnose early gallbladder cancer.

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Is gallbladder cancer prone to spreading?

Gallbladder cancer is a type of cancer that is prone to spreading and is of a higher malignancy level. It is difficult to detect in the early stages. Patients with gallbladder cancer may initially present with subtle right upper abdominal pain, which is often overlooked. Therefore, once diagnosed with gallbladder cancer, it generally has reached the mid to late stages. At this time, the patient's pain becomes significant, which is the primary reason for seeking medical attention. Gallbladder cancer progresses rapidly and is prone to metastasize to other locations, such as the liver, leading to liver dysfunction, jaundice, ascites, hypoalbuminemia, and more. Additionally, for gallbladder cancer, the treatment strategy emphasizes early surgical removal to achieve better therapeutic outcomes.

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Written by Shen Jiang Chao
Radiology
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Gallbladder cancer ultrasonographic appearance

The appearance of gallbladder cancer on color ultrasound depends on the morphology of the cancer, which is mainly divided into five types: small nodular, thick-wall, fragmented, calculous, and mixed type. The small nodular type mainly features a polypoid elevation with a wide base, about 1-1.2 cm in size, and has isoechoic characteristics. The fragmented type is characterized by a wider base and irregular borders, presenting as hypoechoic or isoechoic masses. The calculous type shows an enlarged gallbladder, possibly containing hypoechoic and uneven solid masses that may fill the entire gallbladder. The thick-wall type primarily involves localized or diffuse thickening of the wall. The mixed type is a combination of papillary fragmented type and thick-wall type presence.

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Hepatobiliary Surgery
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The difference between gallbladder polyps and gallbladder cancer in ultrasound examinations

For gallbladder polyps, they are a type of benign tumor, so under color ultrasound, benign protrusions can be observed, and there are no adhesions with surrounding tissues, nor is there obvious blood vessel supply. For gallbladder cancer, it is a type of malignant tumor, so at this time, adhesions with surrounding tissues can be observed under color ultrasound, and there is obvious blood vessel supply. Therefore, for patients with gallbladder polyps and gallbladder cancer, their treatment methods are completely different, and attention should be paid. If it is a gallbladder polyp, patients generally do not exhibit obvious symptoms and do not require special management. For gallbladder cancer patients, however, it severely affects their quality of life and lifespan, so attention must be paid, and early surgical removal and treatment must be undertaken to achieve a cure.

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How long does it take for gallstones to develop into gallbladder cancer?

Gallstones do not necessarily develop into gallbladder cancer. For patients with gallstones, they mainly experience discomfort and pain in the upper right abdomen, especially after overeating or drinking alcohol, when the symptoms suddenly appear. Gallstones do not necessarily cause gallbladder cancer. If symptoms occur, surgery should be performed at this time. Only through surgery can a cure for gallbladder cancer be achieved. It is a common malignant tumor of the gallbladder, mainly caused by repeated inflammatory stimuli or genetic factors. At this time, surgery should be performed to better improve the prognosis of the patient. Early stage gallbladder cancer can be completely removed surgically to achieve a cure.