Is gallbladder cancer prone to spreading?

Written by Liu Wu Cai
Hepatobiliary Surgery
Updated on September 08, 2024
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Gallbladder cancer is a type of cancer that is prone to spreading and is of a higher malignancy level. It is difficult to detect in the early stages. Patients with gallbladder cancer may initially present with subtle right upper abdominal pain, which is often overlooked. Therefore, once diagnosed with gallbladder cancer, it generally has reached the mid to late stages. At this time, the patient's pain becomes significant, which is the primary reason for seeking medical attention. Gallbladder cancer progresses rapidly and is prone to metastasize to other locations, such as the liver, leading to liver dysfunction, jaundice, ascites, hypoalbuminemia, and more. Additionally, for gallbladder cancer, the treatment strategy emphasizes early surgical removal to achieve better therapeutic outcomes.

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Written by Shen Jiang Chao
Radiology
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Gallbladder cancer ultrasonographic appearance

The appearance of gallbladder cancer on color ultrasound depends on the morphology of the cancer, which is mainly divided into five types: small nodular, thick-wall, fragmented, calculous, and mixed type. The small nodular type mainly features a polypoid elevation with a wide base, about 1-1.2 cm in size, and has isoechoic characteristics. The fragmented type is characterized by a wider base and irregular borders, presenting as hypoechoic or isoechoic masses. The calculous type shows an enlarged gallbladder, possibly containing hypoechoic and uneven solid masses that may fill the entire gallbladder. The thick-wall type primarily involves localized or diffuse thickening of the wall. The mixed type is a combination of papillary fragmented type and thick-wall type presence.

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Written by Li Hu Chen
Imaging Center
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Can gallbladder cancer be detected by ultrasound?

If there is gallbladder cancer, we can detect it by conducting an ultrasound examination, checking the liver, gallbladder, pancreas, and spleen, or simply performing an upper abdominal ultrasound. This is because an ultrasound is typically the first choice for examining the hepato-biliary system. Why? Because it's the most convenient and quickest method. Other examinations such as CT scans or MRI often require a prior appointment, especially MRI, which may need booking days in advance. However, ultrasounds are usually done on the same day and the results are immediate, making it the preferred method for examining the liver and gallbladder. Moreover, ultrasound is quite sensitive for gallbladder cancer. It can reveal if the gallbladder wall is particularly thickened, either locally or extensively, which often suggests the presence of gallbladder cancer, or if there is a large mass of soft tissue in the area of the gallbladder fossa, which might also adhere to the surrounding liver, raising suspicions of gallbladder cancer. Additionally, if there are unusually large polyps, particularly those over 1cm or with a notably wide base, gallbladder cancer should also be considered.

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Written by Li Hu Chen
Imaging Center
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Can cholecystitis be detected by color ultrasound?

If there is gallbladder cancer, usually an ultrasonography of the liver and gallbladder or the upper abdomen can detect it. Conditions such as gallbladder cancer or liver cancer are often initially discovered and diagnosed through ultrasound. Of course, the final confirmation of diagnosis is usually achieved through pathological examination after surgery. However, in terms of initial diagnosis, it is very common to identify these conditions through ultrasound. Gallbladder cancer typically presents certain characteristic changes, such as obvious thickening of the gallbladder wall, extensive thickening including sclerosis, and significant soft tissue mass growth extending to and adhering to the liver, which are strong indicators of gallbladder cancer. Additionally, a large polyp may be seen inside the gallbladder, and surgical removal at this stage may diagnose early gallbladder cancer.

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Written by Liu Wu Cai
Hepatobiliary Surgery
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Can people with gallbladder cancer eat lamb?

Patients with gallbladder cancer can appropriately eat mutton, as mutton is a food high in protein, which can supplement the albumin needed by the human body and better improve the patient's resistance. However, patients with gallbladder cancer may experience discomfort such as pain in the upper right abdomen and may also encounter digestive symptoms like indigestion and bloating. Therefore, it is recommended for gallbladder cancer patients to consume foods that are easy to digest, which can reduce the burden on the gastrointestinal tract and facilitate recovery. Although mutton can be consumed, it should be eaten in small, frequent meals to prevent complications such as intestinal obstruction. Additionally, for the treatment of gallbladder cancer, surgical removal should be used as early as possible to achieve a cure, with earlier detection and treatment likely leading to a relatively better prognosis.

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Written by Shen Jiang Chao
Radiology
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The main manifestations of gallbladder cancer on MRI

Gallbladder cancer is more common in females and is generally believed to be associated with chronic stimulation from chronic cholecystitis and gallstones. On MRI, gallbladder cancer can be categorized into several types based on case classification and growth patterns: first, the infiltrative type; second, the nodular type; third, the mass-forming type; and fourth, the obstructive type. Regardless of the pathological type of gallbladder cancer, the tumor tissue appears as a heterogeneous low signal on T1 and a heterogeneous high signal on T2. After enhancement, the tumor shows heterogeneous enhancement. If there is invasion into the liver, the boundary with liver tissue is unclear. MRI has significant advantages in assessing invasion of adjacent organs and metastasis, and can provide great value for surgery or treatment planning.