What is the best treatment for duodenal ulcers?

Written by Si Li Li
Gastroenterology
Updated on December 30, 2024
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The main symptoms of duodenal ulcer include upper abdominal bloating, belching, acid reflux, nausea, vomiting, heartburn, poor appetite, and indigestion. A duodenal ulcer can be diagnosed through a gastroscopy, which reveals the presence of an ulcer in the duodenum. The primary cause of duodenal ulcers is infection by Helicobacter pylori, hence a Carbon-14 breath test is recommended to confirm the presence of H. pylori infection. Roughly 90%-100% of patients with duodenal ulcers are infected with H. pylori. Another common cause is the digestion of the stomach itself by stomach acid and pepsin. Treatment primarily involves eradicating H. pylori, suppressing acid, protecting the stomach, enhancing gastric motility, and protecting the gastric mucosa, with the treatment duration being about six weeks.

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Written by Jiang Guo Ming
Gastroenterology
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Symptoms and Treatment of Duodenal Ulcer

Duodenal bulb ulcers often manifest as hunger-like pain in the upper abdomen, which relieves after eating, accompanied by nocturnal pain. Symptoms also include acid reflux, heartburn, nausea, etc. If there is bleeding, symptoms may include black stools and vomiting blood. Treatment depends on whether there is a Helicobacter pylori infection. If there is a Helicobacter pylori infection, antibacterial treatment is required, commonly using a triple or quadruple antibiotic therapy for two weeks. If there is no Helicobacter pylori infection, symptomatic treatment is sufficient, generally using proton pump inhibitors and gastroprotective medications such as bismuth agents. Additionally, it is important to develop good dietary and lifestyle habits to prevent recurrence.

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Written by Wu Hai Wu
Gastroenterology
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Is duodenal ulcer bleeding a sign of cancerous change?

Duodenal ulcer bleeding does not indicate cancerous changes. The duodenal area is relatively thin, so once a duodenal ulcer occurs, it is more likely to lead to complications such as ulcer bleeding and perforation. If vomiting blood occurs with a duodenal ulcer, it indicates that the patient with the duodenal ulcer has a bleeding complication. In terms of treatment, it is first necessary to complete an endoscopic examination, which can include endoscopic hemostasis; secondly, proton pump inhibitors should be used to suppress the secretion of stomach acid and increase the pH level in the stomach; additionally, treatments that protect the stomach lining, such as aluminum hydroxide and magnesium carbonate, should be used. (Medication should be taken under the guidance of a physician.)

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Written by Zhu Dan Hua
Gastroenterology
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Symptoms of duodenal ulcer

Duodenal ulcers are relatively common in clinical practice and are a frequent condition in gastroenterology. Duodenal ulcers are generally more prevalent among middle-aged individuals, with symptoms most commonly including abdominal pain, bloating, nausea, and vomiting. The abdominal pain typically manifests as upper abdominal pain, usually hunger pain which often improves after eating. It typically presents as long-term, chronic episodes over extended periods and can also occur at night as hunger pain. Therefore, for some typical patients, especially middle-aged individuals, upper abdominal pain should raise concerns about duodenal ulcers. If a patient exhibits symptoms other than abdominal pain, such as black stools, this could suggest bleeding associated with duodenal ulcers, potentially leading to black stools or even vomiting blood. Hence, it is advised that if a patient has symptoms of gastrointestinal bleeding along with abdominal pain, consideration should be given to the possibility of a bleeding duodenal ulcer. It is recommended that such patients undergo thorough gastroscopic examinations to clarify the diagnosis further.

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Written by Si Li Li
Gastroenterology
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What are the symptoms of duodenal ulcers?

The main symptoms of duodenal ulcers include upper abdominal bloating, burping, acid reflux, nausea, vomiting, poor appetite, and indigestion. The characteristic of the upper abdominal pain associated with duodenal ulcers is that the pain intensifies when hungry and decreases after eating. In terms of treatment, the main approach includes acid suppression to protect the stomach, promoting gastric motility, and protecting the gastric mucosa, with the treatment course lasting about six weeks. Additionally, a Carbon-14 breath test is necessary to determine the presence of Helicobacter pylori infection, as Helicobacter pylori has been confirmed as the most important cause of peptic ulcers. If the Helicobacter pylori infection is positive, a 14-day treatment targeting Helicobacter pylori is required, using a regimen of a proton pump inhibitor, two antibiotics, and a bismuth agent.

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Written by Wu Hai Wu
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How large does a duodenal ulcer have to be to be considered severe?

There is no specific size to determine the severity of a duodenal ulcer. However, ulcers with a diameter greater than 1.5 cm are generally considered large. In such cases, strong acid-suppressing medications are needed for treatment, along with drugs to protect the gastric mucosa. Additionally, it is necessary to test for Helicobacter pylori infection. If the infection is positive, a bismuth-containing quadruple therapy should be used for two weeks to eradicate Helicobacter pylori. The choice of specific medications, as well as their dosages and administration, should be under the guidance of a doctor.