Iron deficiency anemia lacks what element?

Written by He Li Fang
Hematology
Updated on March 01, 2025
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Iron deficiency anemia refers to a type of anemia caused by a lack of stored iron in the body, which affects the synthesis of hemoglobin. Its characteristics include a lack of stainable iron in organs such as the bone marrow, liver, and spleen, leading to decreased serum iron concentration, decreased transferrin saturation, and decreased serum ferritin. Typical iron deficiency anemia presents as microcytic hypochromic anemia. Therefore, iron deficiency anemia involves a deficiency in iron, a trace element essential for the human body, which is widely present in cells and participates in the body's metabolic processes. The human body has a strict iron metabolism regulatory mechanism to maintain normal physiological levels. Once this homeostasis is disrupted, it can lead to the occurrence of iron deficiency anemia. Factors that affect the distribution, absorption, transport, and storage of iron can all cause iron deficiency anemia.

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Written by He Li Fang
Hematology
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Causes of Iron Deficiency Anemia

There are many reasons for iron deficiency anemia, which we can categorize into several aspects. The first aspect is a decrease in iron intake, including diet, meaning insufficient dietary intake. The second aspect is decreased absorption, such as the absence of a target organ for absorption or the lack of stomach acid affecting its absorption efficacy. The second aspect refers to excessive loss, most commonly chronic gastrointestinal bleeding, such as in patients with tumors, duodenal ulcers, gastric ulcers, gastritis, ulcerative colitis, a parasitic infection with hookworms, as well as hemorrhoids, and arteriovenous malformations, all of which can cause gastrointestinal bleeding leading to increased iron loss. Excessive menstrual flow in female patients, multiple blood donations, and multiple pregnancies can all lead to iron deficiency. These are the various causes related to iron deficiency.

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Written by He Li Fang
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Symptoms of iron deficiency anemia

The clinical manifestations of iron deficiency anemia consist of symptoms due to the anemia itself, specific manifestations of iron deficiency, and the underlying diseases causing the iron deficiency. The onset of anemia is often insidious, with some patients progressing very slowly. Initially, patients can adapt well to daily life and continue with their work, making it difficult to detect. It is usually not until the anemia becomes moderate to severe and symptoms become apparent that it is discovered. Common symptoms of anemia include dizziness, headaches, weakness, easy fatigue, palpitations, and shortness of breath after activity. Some patients might also experience a decline in memory and suffer from tinnitus and blurred vision. Some affected children may exhibit delayed growth and development or even abnormal behaviors, which can manifest as irritability, restlessness, inattention in class, and declining academic performance. A few patients may develop pica, a specific manifestation of iron deficiency anemia. Additionally, some patients might suffer from angular cheilitis, glossitis, and even atrophy of the tongue papillae. Severe cases can experience transient blindness and fainting, hence it is crucial to seek medical attention for iron deficiency anemia at the earliest.

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Written by He Li Fang
Hematology
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How long does iron deficiency anemia need to be treated?

Patients with iron deficiency anemia typically need several months of iron supplementation treatment. The specific reason is that after taking iron supplements, patients' subjective symptoms can recover quickly. The count of reticulocytes generally begins to rise within three to four days after starting the medication, reaching a peak around seven days. Hemoglobin levels notably increase within two weeks of treatment, and generally return to normal around two months. After correcting anemia, it is necessary to continue treatment for at least another three months because the body's iron stores need further supplementation. It is necessary to restore serum ferritin levels to fifty micrograms per liter to replenish these stores fully. This is required to achieve a true cure of iron deficiency anemia, as without this, patients are prone to relapse. Therefore, regular and long-term effective use of iron supplements is an essential basis for ensuring the treatment effectiveness of iron deficiency anemia.

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Consequences of untreated iron deficiency anemia

Any anemia, if not treated, will only get worse over time, including iron-deficiency anemia. Prolonged anemia can impact various organ systems throughout the body. In the nervous system, it can cause headaches, dizziness, insomnia, frequent dreams, and memory decline. In children, iron-deficiency anemia can even affect intellectual development. In the respiratory system, it can lead to deeper and faster breathing, and increase the risk of respiratory infections. In the circulatory system, it can manifest as low blood volume, and long-term severe anemia can lead to anemic heart disease, causing arrhythmias and heart failure. In the digestive system, it can manifest as reduced appetite, and in severe cases, it can cause constipation, diarrhea, etc.

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Can iron deficiency anemia be cured?

Iron deficiency anemia is treatable, but it is essential to identify the cause of the iron deficiency. The treatment of iron deficiency anemia is divided into two main parts. The first part involves iron supplementation, which can be administered orally or intravenously, with intravenous supplementation generally being more effective and faster. The second part is crucial: identifying the cause of the iron deficiency. For example, common causes in women of childbearing age include heavy menstrual periods, while older patients often suffer from gastrointestinal tumors or ulcers, and in children, the common cause is usually nutritional deficiency. It is vital to treat the underlying cause.