Consequences of untreated iron deficiency anemia

Written by Zhang Xiao Le
Hematology
Updated on January 16, 2025
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Any anemia, if not treated, will only get worse over time, including iron-deficiency anemia. Prolonged anemia can impact various organ systems throughout the body. In the nervous system, it can cause headaches, dizziness, insomnia, frequent dreams, and memory decline. In children, iron-deficiency anemia can even affect intellectual development. In the respiratory system, it can lead to deeper and faster breathing, and increase the risk of respiratory infections. In the circulatory system, it can manifest as low blood volume, and long-term severe anemia can lead to anemic heart disease, causing arrhythmias and heart failure. In the digestive system, it can manifest as reduced appetite, and in severe cases, it can cause constipation, diarrhea, etc.

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Written by Li Fang Fang
Hematology
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Can iron deficiency anemia be cured?

Iron deficiency anemia is treatable, but it is essential to identify the cause of the iron deficiency. The treatment of iron deficiency anemia is divided into two main parts. The first part involves iron supplementation, which can be administered orally or intravenously, with intravenous supplementation generally being more effective and faster. The second part is crucial: identifying the cause of the iron deficiency. For example, common causes in women of childbearing age include heavy menstrual periods, while older patients often suffer from gastrointestinal tumors or ulcers, and in children, the common cause is usually nutritional deficiency. It is vital to treat the underlying cause.

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Written by He Li Fang
Hematology
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Symptoms of iron deficiency anemia

The clinical manifestations of iron deficiency anemia consist of symptoms due to the anemia itself, specific manifestations of iron deficiency, and the underlying diseases causing the iron deficiency. The onset of anemia is often insidious, with some patients progressing very slowly. Initially, patients can adapt well to daily life and continue with their work, making it difficult to detect. It is usually not until the anemia becomes moderate to severe and symptoms become apparent that it is discovered. Common symptoms of anemia include dizziness, headaches, weakness, easy fatigue, palpitations, and shortness of breath after activity. Some patients might also experience a decline in memory and suffer from tinnitus and blurred vision. Some affected children may exhibit delayed growth and development or even abnormal behaviors, which can manifest as irritability, restlessness, inattention in class, and declining academic performance. A few patients may develop pica, a specific manifestation of iron deficiency anemia. Additionally, some patients might suffer from angular cheilitis, glossitis, and even atrophy of the tongue papillae. Severe cases can experience transient blindness and fainting, hence it is crucial to seek medical attention for iron deficiency anemia at the earliest.

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Written by Zhang Xiao Le
Hematology
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Does iron deficiency anemia cause tiredness?

Patients with iron-deficiency anemia can exhibit symptoms of fatigue. Anemia is characterized by red blood cells and hemoglobin levels that are below the normal range. Red blood cells are the main cells responsible for transporting oxygen in the body. Oxygen enters the blood through gas exchange in the lungs and is then delivered throughout the body by red blood cells to supply oxygen. Therefore, patients with anemia will show varying degrees of ischemia and hypoxia. In the nervous system, this can be manifested as lethargy, insomnia, frequent dreaming, tinnitus, blurry vision, fainting, and lack of concentration. As the severity of anemia increases, these symptoms may also worsen. Patients with severe anemia may exhibit significant lethargy and drowsiness.

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Written by He Li Fang
Hematology
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What is the fastest way to treat iron deficiency anemia?

Iron deficiency anemia is a type of anemia caused by a lack of storage iron in the body, affecting the synthesis of hemoglobin. It is characterized by a lack of available iron in tissues and organs such as bone marrow, liver, and spleen, with decreased serum iron concentration, transferrin saturation, and serum ferritin levels. Typically, iron deficiency anemia presents as microcytic hypochromic anemia. Iron, as one of the essential trace elements in the human body, is contained in all functioning cells and is broadly involved in metabolic processes within the body. Therefore, the treatment principle for iron deficiency anemia involves replenishing sufficient iron until normal iron stores are restored and addressing the underlying causes that led to the iron deficiency to effectively and quickly replenish iron. Oral iron supplements are the preferred treatment option for iron deficiency anemia, such as ferrous sulfate, ferrous succinate, and iron dextran which are effective oral iron agents.

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Written by He Li Fang
Hematology
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What are the symptoms of iron deficiency anemia?

Iron deficiency anemia is a type of anemia that exhibits common symptoms found in all anemia patients. It is characterized by a range of clinical symptoms caused by oxygen deficiency in tissue organs due to a lack of blood in the body. Common symptoms include dizziness, headaches, fatigue, shortness of breath and palpitations after activity, easy fatigability, difficulty concentrating, and decreased memory. Some patients may also experience blurred vision, ringing in the ears, and in severe cases, fainting, transient darkening of vision, and even arrhythmias. Because iron deficiency anemia is also accompanied by iron deficiency, it presents a range of clinical symptoms specific to iron deficiency, including pica, angular cheilitis, glossitis, unusual tongue conditions, decreased appetite, and even constipation among other symptoms.